Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | GLA | P06280 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL195410 | 0.79 | ALDH1A1 (0.42) | NPC1RAB9AALDH1A1MAPTGLA | |
| SCHEMBL71079 | 0.79 | NPC1 (0.41) | NPC1RAB9AALDH1A1MAPTGLA | |
| SCHEMBL3234460 | 0.79 | NPC1 (0.41) | NPC1RAB9AALDH1A1MAPTGLA | |
| SCHEMBL9690618 | 0.79 | NPC1 (0.41) | NPC1RAB9AALDH1A1MAPTGLA | |
| SCHEMBL354611 | 0.79 | NPC1 (0.41) | NPC1RAB9AALDH1A1MAPTGLA | |
| SCHEMBL3859298 | 0.79 | NPC1 (0.41) | NPC1RAB9AALDH1A1MAPTGLA | |
| SCHEMBL3735368 | 0.79 | RAB9A (0.45) | NPC1RAB9AALDH1A1MAPTGLA | |
| SCHEMBL7088775 | 0.79 | NPC1 (0.41) | NPC1RAB9AALDH1A1MAPTGLA | |
| SCHEMBL7841262 | 0.78 | RAB9A (0.39) | NPC1RAB9AALDH1A1MAPTGLA | |
| Hydrochloric Acid SCHEMBL1713917 | 0.78 | NPC1 (0.41) | NPC1RAB9AALDH1A1MAPTGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11121327-B2 | Spiro-condensed lactam compounds for organic electroluminescent devices | MERCK PATENT GMBH (DE) | 2021-09-14 | — | — | US | disclosed |
| EP-3016952-B1 | SPIRO-CONDENSED LACTAM COMPOUNDS FOR ORGANIC ELECTROLUMINESCENT DEVICES | MERCK PATENT GMBH (DE) | 2019-05-15 | — | — | EP | disclosed |
| US-20160372681-A1 | SPIRO-CONDENSED LACTAM COMPOUNDS FOR ORGANIC ELECTROLUMINESCENT DEVICES | MERCK PATENT GMBH (DE) | 2016-12-22 | — | — | US | disclosed |
| EP-3016952-A1 | SPIRO-CONDENSED LACTAM COMPOUNDS FOR ORGANIC ELECTROLUMINESCENT DEVICES | Merck Patent GmbH (DE) | 2016-05-11 | — | — | EP | disclosed |
| WO-2015000542-A1 | SPIRO-CONDENSED LACTAM COMPOUNDS FOR ORGANIC ELECTROLUMINESCENT DEVICES | MERCK PATENT GMBH (DE) | 2015-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11121327-B2 | Spiro-condensed lactam compounds for organic electroluminescent devices | PORCN, COASY, AAAS | NPC1 3971/4885RAB9A 1790/4885ALDH1A1 2105/4885 |
| US-20160372681-A1 | SPIRO-CONDENSED LACTAM COMPOUNDS FOR ORGANIC ELECTROLUMINESCENT DEVICES | PORCN, COASY, AAAS | NPC1 3971/4885RAB9A 1790/4885ALDH1A1 2105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.