Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | RXRG | P48443 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9691625 | 0.92 | NR1I2 (0.42) | KMT2AHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10647011 | 0.89 | HTR1A (0.39) | KMT2AMEN1HTR1ASLC6A2SLC6A4 | |
| SCHEMBL10814309 | 0.86 | TP53 (0.45) | KMT2AMEN1HTR1ASLC6A2SLC6A4 | |
| SCHEMBL10647036 | 0.86 | CYP3A4 (0.41) | KMT2AMEN1HTR1ASLC6A2SLC6A4 | |
| SCHEMBL9691359 | 0.85 | POLB (0.44) | KMT2AMEN1HTR1ASLC6A2SLC6A4 | |
| SCHEMBL9691648 | 0.85 | TP53 (0.41) | KMT2AMEN1TP53POLBSMN1; SMN2 | |
| SCHEMBL10644589 | 0.84 | KMT2A (0.45) | KMT2AMEN1TP53POLBSMN1; SMN2 | |
| SCHEMBL10818189 | 0.83 | TP53 (0.41) | KMT2AMEN1TP53POLBSMN1; SMN2 | |
| SCHEMBL10644308 | 0.83 | KMT2A (0.44) | KMT2AMEN1TP53POLBSMN1; SMN2 | |
| SCHEMBL10647671 | 0.83 | NR1I2 (0.39) | KMT2AHTR1ASLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0071819-B2 | DIHYDROPYRIDINES WITH A POSITIVE INOTROPIC ACTIVITY, THEIR USE IN PHARMACEUTICAL PREPARATIONS, AND PROCESSES FOR THEIR PREPARATION | BAYER AG (DE) | 1992-06-10 | — | — | EP | disclosed |
| EP-0071819-B1 | DIHYDROPYRIDINES WITH A POSITIVE INOTROPIC ACTIVITY, THEIR USE IN PHARMACEUTICAL PREPARATIONS, AND PROCESSES FOR THEIR PREPARATION | BAYER AG (DE) | 1987-04-22 | — | — | EP | disclosed |