SCHEMBL9692252

SCHEMBL9692252

COC(=O)C1OC1(C)c1ccc(N(C)C)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.45
TSHR P16473 2/20 0.40
MAPT P10636 5/20 0.38
HPGD P15428 4/20 0.38
NPC1 O15118 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
RAB9A P51151 2/20 0.38
TP53 P04637 1/20 0.38
ESR2 Q92731 1/20 0.38
NOX1 Q9Y5S8 1/20 0.38
ITGA4 P13612 1/20 0.37
TDP1 Q9NUW8 2/20 0.36
POLB P06746 1/20 0.36
KDM4E B2RXH2 2/20 0.36
MEN1 O00255 1/20 0.36
THRB P10828 1/20 0.36
GFER P55789 1/20 0.36
KMT2A Q03164 1/20 0.36
HDAC1 Q13547 2/20 0.36
ATM Q13315 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9691713 0.83 SLC6A3 (0.38) ALDH1A1MAPTHPGDSMN1; SMN2ITGA4
SCHEMBL9691988 0.83 TDP1 (0.39) ALDH1A1MAPTSMN1; SMN2ITGA4TDP1
SCHEMBL9692259 0.81 ATM (0.50) ALDH1A1HPGDNPC1SMN1; SMN2RAB9A
SCHEMBL9692273 0.81 SLC6A3 (0.37) ALDH1A1MAPTNPC1SMN1; SMN2RAB9A
SCHEMBL11479516 0.81 SLC6A4 (0.37) ALDH1A1MAPTITGA4ATML3MBTL1
SCHEMBL8115242 0.81 HTT (0.53) ALDH1A1TSHRMAPTITGA4POLB
SCHEMBL9692296 0.80 RAB9A (0.46) ALDH1A1TSHRMAPTHPGDNPC1
SCHEMBL11654495 0.79 HTT (0.44) ALDH1A1TSHRMAPTSMN1; SMN2ITGA4
SCHEMBL9690238 0.79 ALDH1A1 (0.39) ALDH1A1MAPTNPC1SMN1; SMN2RAB9A
SCHEMBL9690185 0.79 SLC6A2 (0.42) ALDH1A1MAPTHPGDNPC1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0153692-B1 METHOD FOR ISOMERIZATION A GLYCIDATE DERIVATIVE SAGAMI CHEMICAL RESEARCH CENTER (JP) 1992-07-29 EP disclosed
US-4621150-A METAL PERHALATE OR SULFONATE OR COMPLEX; GLYCIDATE, 2-HYDROXY-3-BUTENOATE, EPOXIDE SAGAMI CHEMICAL RESEARCH CENTER (JP) 1986-11-04 US disclosed
EP-0153692-A2 Method for isomerization a glycidate derivative SAGAMI CHEMICAL RESEARCH CENTER (JP) 1985-09-04 EP disclosed