Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | AR | P10275 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | GALR3 | O60755 | 2/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | GCGR | P47871 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9123290 | 0.89 | SMN1; SMN2 (0.53) | SMN1; SMN2RAB9AMAPTKDM4EKMT2A | |
| SCHEMBL12576912 | 0.82 | AR (0.65) | SMN1; SMN2RAB9AMAPTKMT2ALMNA | |
| SCHEMBL9222642 | 0.82 | PTGES (0.47) | SMN1; SMN2MAPTKDM4EKMT2ALMNA | |
| SCHEMBL9124267 | 0.79 | MAPT (0.50) | SMN1; SMN2RAB9AMAPTKMT2ALMNA | |
| SCHEMBL9125655 | 0.79 | APEX1 (0.51) | SMN1; SMN2RAB9AMAPTKDM4EKMT2A | |
| SCHEMBL9693018 | 0.79 | RAB9A (0.62) | SMN1; SMN2RAB9AMAPTKDM4EKMT2A | |
| SCHEMBL9124612 | 0.78 | MAPT (0.51) | SMN1; SMN2RAB9AMAPTKDM4EKMT2A | |
| SCHEMBL9693067 | 0.77 | TSHR (0.41) | SMN1; SMN2RAB9AMAPTKDM4EKMT2A | |
| SCHEMBL9692997 | 0.77 | EGFR (0.50) | KMT2ALMNAMEN1HTTALDH1A1 | |
| SCHEMBL14864569 | 0.76 | SMN1; SMN2 (0.46) | SMN1; SMN2RAB9AMAPTKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0520552-A1 | Derivatives of (hetero) aromatic ethers and thioethers having antihyperlipidemic activity, process for their preparation and pharmaceutical compositions containing them | PIERREL S.p.A. (IT) | 1992-12-30 | — | — | EP | claimed |