Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | GALR3 | O60755 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9692116 | 0.91 | GAA (0.51) | MAPTRAB9AMAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL9692370 | 0.91 | ADRB2 (0.41) | MAPTRAB9AMAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL9124114 | 0.85 | RAB9A (0.50) | MAPTRAB9AMAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL9124271 | 0.85 | RAB9A (0.47) | MAPTRAB9AMAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL9690639 | 0.82 | LMNA (0.48) | MAPTL3MBTL1SMN1; SMN2TSHRKMT2A | |
| SCHEMBL9692797 | 0.82 | MAPT (0.43) | MAPTRAB9AMAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL9241996 | 0.80 | RAB9A (0.39) | MAPTRAB9AMAPK1SMN1; SMN2NPC1 | |
| SCHEMBL9125655 | 0.79 | APEX1 (0.51) | MAPTRAB9AMAPK1SMN1; SMN2TSHR | |
| SCHEMBL9693206 | 0.79 | SMN1; SMN2 (0.52) | MAPTRAB9AMAPK1SMN1; SMN2TSHR | |
| SCHEMBL9693018 | 0.79 | RAB9A (0.62) | MAPTRAB9AMAPK1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0520552-A1 | Derivatives of (hetero) aromatic ethers and thioethers having antihyperlipidemic activity, process for their preparation and pharmaceutical compositions containing them | PIERREL S.p.A. (IT) | 1992-12-30 | — | — | EP | claimed |
| US-5470858-A | Anticholesterol agents | PIERREL SPA (IT) | 1995-11-28 | — | — | US | disclosed |
| EP-0520552-A1 | Derivatives of (hetero) aromatic ethers and thioethers having antihyperlipidemic activity, process for their preparation and pharmaceutical compositions containing them | PIERREL S.p.A. (IT) | 1992-12-30 | — | — | EP | disclosed |