Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.54 |
| ▸ | PTAFR | P25105 | 1/20 | 0.54 |
| ▸ | HTR1D | P28221 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9863905 | 0.98 | ADRA1D (0.54) | ADRA1DPTAFRHTR1DHTR2CADRA1B | |
| Iodide SCHEMBL9863487 | 0.91 | ADRA1D (0.45) | ADRA1DPTAFRHTR1DHTR2CADRA1B | |
| SCHEMBL9863415 | 0.85 | ADRA1D (0.44) | ADRA1DPTAFRHTR1DHTR2CADRA1B | |
| Hydrochloric Acid SCHEMBL9863421 | 0.84 | LPAR5 (0.43) | ADRA1DPTAFRHTR1DHTR2CADRA1B | |
| Iodide SCHEMBL9863389 | 0.83 | PRKD3 (0.44) | — | |
| Iodide SCHEMBL9863345 | 0.83 | PLA2G2C (0.53) | — | |
| Hydrochloric Acid SCHEMBL9863873 | 0.81 | ADRA1D (0.43) | ADRA1DPTAFRHTR1DHTR2CADRA1B | |
| Bromide SCHEMBL9498730 | 0.79 | ADRA1D (0.67) | ADRA1DPTAFRHTR1DHTR2CADRA1B | |
| Hydrochloric Acid SCHEMBL9863634 | 0.76 | DNM1 (0.36) | — | |
| SCHEMBL10824976 | 0.76 | ADRA1D (0.55) | ADRA1DPTAFRHTR1DHTR2CADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-60243047-A | — | — | None | — | — | JP | disclosed |
| EP-0157609-B1 | LIPID DERIVATIVES THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1992-10-14 | — | — | EP | disclosed |
| US-5025005-A | Preventive or therapeutic agents for circulatory diseases, allergic disorders; antineoplastic agent; inhibitor for platelet activating factor | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1991-06-18 | — | — | US | disclosed |
| US-4737518-A | ANTIALLERGENS, ANTINEOPLASTICS, ANTICOAGULANTS, CIRCULATORY DISEASES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1988-04-12 | — | — | US | disclosed |
| JP-S60243047-A | LIPID DERIVATIVE | TAKEDA CHEM IND LTD | 1985-12-03 | — | — | JP | disclosed |