Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.45 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | S100A4 | P26447 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11521456 | 0.85 | ATM (0.49) | TDP1HSPB1ALDH1A1TSHRMEN1 | |
| SCHEMBL29044667 | 0.84 | TDP1 (0.47) | TDP1GPR35HSPB1ALDH1A1MEN1 | |
| SCHEMBL17109851 | 0.83 | TDP1 (0.48) | TDP1GPR35HSPB1ALDH1A1TSHR | |
| SCHEMBL1995565 | 0.81 | TDP1 (0.47) | TDP1GPR35ALDH1A1TSHRMEN1 | |
| SCHEMBL16953540 | 0.79 | TDP1 (0.45) | TDP1GPR35ALDH1A1TSHRMEN1 | |
| SCHEMBL4728834 | 0.79 | HPGD (0.46) | TDP1GPR35ALDH1A1TSHRMEN1 | |
| SCHEMBL10338398 | 0.79 | TSHR (0.58) | TDP1GPR35ALDH1A1TSHRMEN1 | |
| SCHEMBL9905068 | 0.79 | TDP1 (0.45) | TDP1GPR35ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL11375306 | 0.79 | GPR35 (0.56) | TDP1GPR35ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL4520380 | 0.79 | TDP1 (0.45) | TDP1GPR35ALDH1A1TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110088086-A | Disubstituted maleic amide class connexon and its preparation method and application for antibody-drug conjugate | 迈威(上海)生物科技有限公司 | 2019-08-02 | — | — | CN | disclosed |
| CN-109810039-A | Disubstituted maleimide-based linker for antibody-drug coupling, preparation method and application thereof | 上海青润医药科技有限公司 | 2019-05-28 | — | — | CN | disclosed |
| CN-106458939-B | * oxazolidinyl compound and the selective androgen receptor agonist comprising the compound | 东亚ST株式会社 | 2019-05-17 | — | — | CN | disclosed |
| CN-109071563-A | Inhibitors of bruton's tyrosine kinase and methods of use thereof | 詹森药业有限公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-108431001-A | Ring-fused pyrimidines compound or its salt | 大鹏药品工业株式会社 | 2018-08-21 | — | — | CN | disclosed |
| CN-104884453-B | Anthelmintic compounds and compositions and methods of using the same | 梅里亚股份有限公司 | 2018-06-22 | — | — | CN | disclosed |
| CN-105339355-B | Novel CYP17 inhibitor/antiandrogen | 奥赖恩公司 | 2018-02-27 | — | — | CN | disclosed |
| CN-107652293-A | Imidazopyridazines IRAK4 inhibitor and its preparation method and application | 中国药科大学 | 2018-02-02 | — | — | CN | disclosed |
| CN-106029661-B | Pyrazolo [1,5-A ] pyridine derivatives and methods of use thereof | 亚尼塔公司 | 2017-11-03 | — | — | CN | disclosed |
| CN-107257793-A | Anti- worm compound, composition and its application method | 梅里亚股份有限公司 | 2017-10-17 | — | — | CN | disclosed |
| CN-101821266-B | Modulators of cystic fibrosis transmembrane channel regulators | VERTEX PHARMA | 2014-03-12 | — | — | CN | disclosed |
| CN-102459186-A | Anthelmintic agents and uses thereof | ANTHELMINTIC AGENTS AND THEIR USE | 2012-05-16 | — | — | CN | disclosed |
| CN-1863789-A | Substituted isoquinolinones | PORTOLA PHARM INC (US) | 2006-11-15 | — | — | CN | disclosed |
| EP-0270964-B1 | PROCESS FOR OBTAINING SUBSTITUTED FLUOROBENZENES | BAYER AG (DE) | 1992-07-08 | — | — | EP | disclosed |
| US-4868347-A | SOLVENT EXTRACTION | BAYER AKTIENGESELLSCHAFT (DE) | 1989-09-19 | — | — | US | disclosed |
| EP-0270964-A2 | Process for obtaining substituted fluorobenzenes | BAYER AG (DE) | 1988-06-15 | — | — | EP | disclosed |
| US-4224340-A | Anti-inflammatory compositions containing α-phenyl-N-phenylnitrone compounds | WILLIAM H. RORER, INC. (US) | 1980-09-23 | — | — | US | disclosed |
| US-4214003-A | ANTIINFLAMMATORY AGENTS | WILLIAM H. RORER, INC. (US) | 1980-07-22 | — | — | US | disclosed |
| US-4197314-A | WITH A DIPHENYL NITRONE | WILLIAM H. RORER, INC. (US) | 1980-04-08 | — | — | US | disclosed |
| US-4153722-A | ANTIINFLAMMATORY, A-PHENYL-N-PHENYLNITRONE | WILLIAM H. RORER, INC. (US) | 1979-05-08 | — | — | US | disclosed |