Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.46 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.46 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27176600 | 0.82 | APEX1 (0.42) | HPGDTDP1ALDH1A1TSHRCYP3A4 | |
| SCHEMBL6886786 | 0.81 | TDP1 (0.48) | HPGDTDP1ALDH1A1TSHRCYP1A2 | |
| SCHEMBL1995565 | 0.79 | TDP1 (0.47) | HPGDTDP1ALDH1A1TSHRCYP3A4 | |
| SCHEMBL9694041 | 0.79 | TDP1 (0.47) | HPGDTDP1ALDH1A1TSHRCYP3A4 | |
| SCHEMBL9905068 | 0.78 | TDP1 (0.45) | HPGDTDP1ALDH1A1TSHRCYP3A4 | |
| SCHEMBL11375306 | 0.78 | GPR35 (0.56) | TDP1ALDH1A1TSHRGPR35SMN1; SMN2 | |
| SCHEMBL4520380 | 0.78 | TDP1 (0.45) | HPGDTDP1ALDH1A1TSHRCYP3A4 | |
| SCHEMBL10338398 | 0.78 | TSHR (0.58) | TDP1ALDH1A1TSHRGPR35MEN1 | |
| SCHEMBL16953540 | 0.78 | TDP1 (0.45) | HPGDTDP1ALDH1A1TSHRCYP3A4 | |
| SCHEMBL28303063 | 0.78 | ALDH1A1 (0.46) | TDP1ALDH1A1TSHRCYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107793413-A | Pyrimidine heterocyclic compound and its preparation method and application | 天津滨江药物研发有限公司 | 2018-03-13 | — | — | CN | disclosed |
| WO-2008084324-A1 | NAPHTHYRIDINONE COMPOUND | PFIZER PRODUCTS INC. (US) | 2008-07-17 | — | — | WO | disclosed |
| WO-2008084324-A1 | NAPHTHYRIDINONE COMPOUND | PFIZER PRODUCTS INC. (US) | 2008-07-17 | — | — | WO | disclosed |
| US-20080167319-A1 | 7-(4-(4-[3-CHLORO-2-(TRIFLUOROMETHYL)PHENYL]PIPERAZIN-1-YL)BUTOXY)-[1,8]-NAPHTHYRIDIN-2(1H)-ONE | PFIZER INC. | 2008-07-10 | — | — | US | disclosed |
| US-20080167319-A1 | 7-(4-(4-[3-CHLORO-2-(TRIFLUOROMETHYL)PHENYL]PIPERAZIN-1-YL)BUTOXY)-[1,8]-NAPHTHYRIDIN-2(1H)-ONE | PFIZER INC. | 2008-07-10 | — | — | US | disclosed |
| US-20080167319-A1 | 7-(4-(4-[3-CHLORO-2-(TRIFLUOROMETHYL)PHENYL]PIPERAZIN-1-YL)BUTOXY)-[1,8]-NAPHTHYRIDIN-2(1H)-ONE | PFIZER INC. | 2008-07-10 | — | — | US | disclosed |
| WO-2008020306-A2 | ISOINDOLE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2008-02-21 | — | — | WO | disclosed |
| WO-2008020306-A2 | ISOINDOLE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2008-02-21 | — | — | WO | disclosed |
| US-4224340-A | Anti-inflammatory compositions containing α-phenyl-N-phenylnitrone compounds | WILLIAM H. RORER, INC. (US) | 1980-09-23 | — | — | US | disclosed |
| US-4214003-A | ANTIINFLAMMATORY AGENTS | WILLIAM H. RORER, INC. (US) | 1980-07-22 | — | — | US | disclosed |
| US-4197314-A | WITH A DIPHENYL NITRONE | WILLIAM H. RORER, INC. (US) | 1980-04-08 | — | — | US | disclosed |
| US-4153722-A | ANTIINFLAMMATORY, A-PHENYL-N-PHENYLNITRONE | WILLIAM H. RORER, INC. (US) | 1979-05-08 | — | — | US | disclosed |
| US-4110405-A | One step process for preparing 2,6-dinitro-4-trifluoromethylchlorobenzene by nitration of 4-trifluoromethylchlorobenzene | MONTEDISON S.P.A. (IT) | 1978-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167319-A1 | 7-(4-(4-[3-CHLORO-2-(TRIFLUOROMETHYL)PHENYL]PIPERAZIN-1-YL)BUTOXY)-[1,8]-NAPHTHYRIDIN-2(1H)-ONE | BDNF, SCN7A, GRIN2C | HPGD 2103/4885TDP1 1455/4885ALDH1A1 290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.