Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Clorazepic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | ALB | P02768 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.72 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.64 |
| ▸ | CCKBR | P32239 | 4/20 | 0.60 |
| ▸ | CNR1 | P21554 | 1/20 | 0.54 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | PGR | P06401 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clorazepic Acid SCHEMBL34617 | 0.99 | LMNA (0.73) | LMNAMEN1ALBKMT2ACHRM1 | |
| Clorazepic Acid SCHEMBL34618 | 0.99 | LMNA (0.73) | LMNAMEN1ALBKMT2ACHRM1 | |
| Clorazepic Acid SCHEMBL29484725 | 0.99 | LMNA (0.73) | LMNAMEN1ALBKMT2ACHRM1 | |
| Clorazepic Acid SCHEMBL1649064 | 0.99 | LMNA (0.73) | LMNAMEN1ALBKMT2ACHRM1 | |
| Clorazepic Acid SCHEMBL27617141 | 0.98 | LMNA (0.72) | LMNAMEN1ALBKMT2ACHRM1 | |
| Clorazepic Acid SCHEMBL1302660 | 0.98 | LMNA (0.72) | LMNAMEN1ALBKMT2ACHRM1 | |
| Clorazepic Acid SCHEMBL4287456 | 0.98 | LMNA (0.72) | LMNAMEN1ALBKMT2ACHRM1 | |
| Clorazepic Acid SCHEMBL236792 | 0.98 | LMNA (0.72) | LMNAMEN1ALBKMT2ACHRM1 | |
| Clorazepic Acid SCHEMBL29374553 | 0.96 | LMNA (0.70) | LMNAMEN1ALBKMT2ACHRM1 | |
| Clorazepic Acid SCHEMBL21462311 | 0.96 | LMNA (0.70) | LMNAMEN1ALBKMT2ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0182765-B1 | ELECTROCHEMICAL CONTROLLED RELEASE DRUG DELIVERY SYSTEM | THE REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 1992-08-26 | — | — | EP | disclosed |
| EP-0182765-A2 | Electrochemical controlled release drug delivery system | THE REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 1986-05-28 | — | — | EP | disclosed |
| US-4585652-A | REDOX SITES ON CHARGED POLYMER | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 1986-04-29 | — | — | US | disclosed |