Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 13/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9780839 | 0.82 | ALDH1A1 (0.34) | GCGRTHRBTGFBR1PTGS2KMT2A | |
| SCHEMBL9696143 | 0.79 | KMT2A (0.53) | PTGS2KMT2APTGS1 | |
| SCHEMBL9695099 | 0.79 | PTGS2 (0.39) | PTGS2KMT2APTGS1 | |
| SCHEMBL9696155 | 0.77 | KMT2A (0.35) | GCGRTHRBTGFBR1PTGS2KMT2A | |
| SCHEMBL9697138 | 0.76 | KMT2A (0.34) | GCGRTHRBTGFBR1PTGS2KMT2A | |
| SCHEMBL9696224 | 0.73 | HMGCR (0.38) | THRB | |
| SCHEMBL9696237 | 0.73 | HMGCR (0.37) | THRB | |
| SCHEMBL9696231 | 0.73 | HMGCR (0.37) | THRB | |
| SCHEMBL6290810 | 0.71 | RIPK3 (0.45) | KMT2A | |
| SCHEMBL2654771 | 0.69 | GCGR (0.67) | GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5124453-A | Treatment of corresponding aldehyde with lithium bis(tri-methylsilyl)amide | E. R. SQUIBB & SONS, INC. (US) | 1992-06-23 | — | — | US | disclosed |
| EP-0444532-A1 | Phosphorus-containing HMG-CoA reductase inhibitors, new intermediates and method | E.R. SQUIBB & SONS, INC. (US) | 1991-09-04 | — | — | EP | disclosed |
| US-5025000-A | Anticholesterol, antilipemic agents | E. R. SQUIBB & SONS, INC. (US) | 1991-06-18 | — | — | US | disclosed |