Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | GCGR | P47871 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | USP7 | Q93009 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9697139 | 0.84 | ALDH1A1 (0.41) | MEN1KMT2AALDH1A1KDM4EFLT3 | |
| SCHEMBL10691696 | 0.80 | ALDH1A1 (0.36) | MEN1KMT2AALDH1A1KDM4EFLT3 | |
| SCHEMBL9696134 | 0.76 | GCGR (0.39) | MEN1KMT2AALDH1A1KDM4EFLT3 | |
| SCHEMBL10693357 | 0.76 | HMGCR (0.46) | ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL9696278 | 0.75 | IDO1 (0.44) | MEN1KMT2AALDH1A1KDM4EFLT3 | |
| SCHEMBL6241912 | 0.72 | HMGCR (0.57) | ESR1 | |
| SCHEMBL6327616 | 0.72 | HMGCR (0.57) | ESR1 | |
| SCHEMBL10679732 | 0.72 | HMGCR (0.57) | ESR1 | |
| SCHEMBL10696309 | 0.69 | HMGCR (0.39) | MEN1KMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL10696887 | 0.69 | HMGCR (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5124453-A | Treatment of corresponding aldehyde with lithium bis(tri-methylsilyl)amide | E. R. SQUIBB & SONS, INC. (US) | 1992-06-23 | — | — | US | disclosed |
| EP-0444532-A1 | Phosphorus-containing HMG-CoA reductase inhibitors, new intermediates and method | E.R. SQUIBB & SONS, INC. (US) | 1991-09-04 | — | — | EP | disclosed |
| US-5025000-A | Anticholesterol, antilipemic agents | E. R. SQUIBB & SONS, INC. (US) | 1991-06-18 | — | — | US | disclosed |