Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.58 |
| ▸ | ECE1 | P42892 | 14/20 | 0.56 |
| ▸ | MME | P08473 | 13/20 | 0.56 |
| ▸ | MMP8 | P22894 | 1/20 | 0.56 |
| ▸ | MMP14 | P50281 | 1/20 | 0.56 |
| ▸ | MMP1 | P03956 | 1/20 | 0.54 |
| ▸ | MMP3 | P08254 | 1/20 | 0.54 |
| ▸ | KYNU | Q16719 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9715090 | 0.94 | MMP8 (0.64) | ACE2ECE1MMEMMP8MMP14 | |
| SCHEMBL9715281 | 0.91 | ACE2 (0.62) | ACE2ECE1MMEKYNU | |
| SCHEMBL9697261 | 0.91 | MMP8 (0.55) | ACE2ECE1MMEMMP8MMP14 | |
| SCHEMBL9697199 | 0.90 | ACE2 (0.70) | ACE2ECE1MMEMMP8MMP14 | |
| SCHEMBL9715129 | 0.90 | ACE2 (0.50) | ACE2ECE1MMEMMP8MMP14 | |
| SCHEMBL9715088 | 0.89 | ECE1 (0.60) | ACE2ECE1MMEMMP8MMP14 | |
| SCHEMBL9698508 | 0.89 | MMP8 (0.59) | ACE2ECE1MMEMMP8MMP14 | |
| SCHEMBL9715136 | 0.87 | ACE2 (0.69) | ACE2ECE1MME | |
| SCHEMBL6928745 | 0.83 | ECE1 (0.77) | ACE2ECE1MMEMMP8MMP14 | |
| SCHEMBL9715155 | 0.83 | ECE1 (0.50) | ACE2ECE1MMEMMP8MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5143908-A | Carboxylic acids containing amino and phosphinyl groups | MERCK & CO., INC. (US) | 1992-09-01 | — | — | US | disclosed |
| US-5099063-A | 3-(1-aminoalkylphosphinyl)-(2-substituted)propionic acids | MERCK & CO., INC. (US) | 1992-03-24 | — | — | US | disclosed |
| US-4715994-A | PHOSPHINIC ACID DERIVATIVES | MERCK & CO., INC. (US) | 1987-12-29 | — | — | US | disclosed |