SCHEMBL9699718

SCHEMBL9699718

CCOC(=O)N1CCC(N(C)c2nc3ccccc3n2Cc2ccc(F)cc2)CC1

nearest known ligand 0.56

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
HRH1 P35367 14/20 0.56
CYP2D6 P10635 12/20 0.56
KCNH2 Q12809 7/20 0.55
CHRM1 P11229 6/20 0.53
HRH3 Q9Y5N1 5/20 0.51
ADRA2A P08913 1/20 0.51
HTR2B P41595 1/20 0.51
PDE4D Q08499 1/20 0.51
PDE3A Q14432 1/20 0.51
TP53 P04637 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9564844 0.82 CYP1A2 (0.50) HRH1CYP2D6TP53
SCHEMBL9535563 0.81 TP53 (0.51) HRH1CYP2D6KCNH2CHRM1TP53
SCHEMBL9266568 0.81 HRH1 (0.66) HRH1CYP2D6KCNH2TP53
SCHEMBL6995354 0.81 LMNA (0.71) HRH1CYP2D6KCNH2CHRM1HRH3
SCHEMBL12045388 0.80 HRH1 (0.65) HRH1CYP2D6KCNH2CHRM1ADRA2A
SCHEMBL9699714 0.79 ALDH1A1 (0.53) HRH1CYP2D6KCNH2CHRM1HRH3
Hydrochloric Acid SCHEMBL11470684 0.79 SSTR5 (0.65) HRH1CYP2D6KCNH2CHRM1HRH3
SCHEMBL10338043 0.78 HRH1 (0.71) HRH1CYP2D6KCNH2CHRM1ADRA2A
SCHEMBL9629294 0.78 LMNA (0.67) HRH1CYP2D6KCNH2CHRM1HRH3
Hydrochloric Acid SCHEMBL9699716 0.78 KCNH2 (0.59) HRH1CYP2D6KCNH2CHRM1ADRA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE33833-E Intermediates for antihistamines, antiserotonine agents JANSSEN PHARMACEUTICA N.V. (BE) 1992-02-25 US disclosed
US-4820822-A ANTIHISTAMINE, ANTISEROTONINE AGENTS JANSSEN PHARMACEUTICA (BE) 1989-04-11 US disclosed
US-4760074-A Novel-N-(bicyclic heterocyclyl)-4-piperidinamines JANSSEN PHARMACEUTICA N.V. (BE) 1988-07-26 US disclosed
EP-0099139-B1 NOVEL N-(BICYCLIC HETEROCYCLYL)-4-PIPERIDINAMINES JANSSEN PHARMACEUTICA N.V. (BE) 1987-02-11 EP disclosed
US-4556660-A ANTIALLERGENS JANSSEN PHARMACEUTICA N.V. (BE) 1985-12-03 US disclosed
EP-0099139-A2 Novel N-(bicyclic heterocyclyl)-4-piperidinamines JANSSEN PHARMACEUTICA N.V. (BE) 1984-01-25 EP disclosed