SCHEMBL9700422

SCHEMBL9700422

Cc1cc(C)c(S(=O)(=O)F)cc1C=O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRIA1 P42261 1/20 0.41
GRIA2 P42262 1/20 0.41
GRIA3 P42263 1/20 0.41
GRIA4 P48058 1/20 0.41
ALDH1A1 P00352 3/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
TSHR P16473 2/20 0.35
ERN1 O75460 1/20 0.34
RAPGEF4 Q8WZA2 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C19 P33261 1/20 0.34
NPC1 O15118 1/20 0.34
PKM P14618 1/20 0.34
RAB9A P51151 1/20 0.34
MEN1 O00255 2/20 0.33
MAPT P10636 2/20 0.33
KMT2A Q03164 2/20 0.33
KDM4E B2RXH2 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9698072 0.82 GRIA1 (0.40) GRIA1GRIA2GRIA3GRIA4ALDH1A1
SCHEMBL9700291 0.79 RAPGEF4 (0.38) GRIA1GRIA2GRIA3GRIA4ALDH1A1
SCHEMBL7119052 0.77 GRIA1 (0.47) GRIA1GRIA2GRIA3GRIA4ALDH1A1
SCHEMBL18128766 0.77 GRIA1 (0.54) GRIA1GRIA2GRIA3GRIA4ALDH1A1
SCHEMBL97117 0.74 GRIA1 (0.52) GRIA1GRIA2GRIA3GRIA4ALDH1A1
SCHEMBL2884919 0.74 GRIA1 (0.56) GRIA1GRIA2GRIA3GRIA4ALDH1A1
SCHEMBL9700245 0.72 CYP2A6 (0.40) ALDH1A1SMN1; SMN2TSHRNPC1RAB9A
SCHEMBL9699103 0.72 ALDH1A1 (0.42) GRIA1GRIA2GRIA3GRIA4ALDH1A1
SCHEMBL27371469 0.71 GRIA1 (0.42) GRIA1GRIA2GRIA3GRIA4ALDH1A1
SCHEMBL9700460 0.71 ALDH1A1 (0.33) ALDH1A1PTGS2L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2078654-A None JP disclosed
US-5095150-A FORMYLATED ALKLBENZENESULFONYL HALIDE COMPOUND AND PROCESS FOR PREPARING THE SAME AGENCY OF INDUSTRIAL SCIENCE & TECHNOLOGY (JP) 1992-03-10 US disclosed
US-5030752-A Formylated alkylbenzenesulfonyl halide compound AGENCY OF INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 1991-07-09 US disclosed
JP-H0278654-A FORMYLDIALKYLBENZENESULFONYL HALIDE AND PRODUCTION THEREOF AGENCY OF IND SCIENCE & TECHNOL 1990-03-19 JP disclosed