Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 14/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PDE6D | O43924 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | PDE9A | O76083 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | PDE6A | P16499 | 1/20 | 0.35 |
| ▸ | PDE6G | P18545 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE6B | P35913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9701582 | 0.93 | GCGR (0.39) | PDE5AMAOAMAOBALDH1A1KMT2A | |
| SCHEMBL9525805 | 0.88 | CDC7 (0.36) | MAOAMAOBKMT2AMEN1MAPT | |
| SCHEMBL7644729 | 0.86 | PDE5A (0.47) | PDE5AALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL9701474 | 0.84 | CYP1A2 (0.41) | ALDH1A1MAPTKDM4ECYP1A2HPGD | |
| SCHEMBL9700689 | 0.84 | RAB9A (0.33) | PDE5AMAOAMAOBALDH1A1KMT2A | |
| SCHEMBL9526113 | 0.83 | MAPT (0.41) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL9524898 | 0.81 | PDE4A (0.37) | PDE5AALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL9526401 | 0.81 | PTPN1 (0.36) | KMT2AMEN1MAPTUSP2LMNA | |
| SCHEMBL9701387 | 0.80 | CYP2C9 (0.47) | LMNACYP1A2HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL9701382 | 0.80 | SMN1; SMN2 (0.42) | ALDH1A1KMT2AMEN1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992006085-A1 | PHENYLPYRIDINOL DERIVATIVES AS MEDICAMENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1992-04-16 | — | — | WO | claimed |
| WO-1992006085-A1 | PHENYLPYRIDINOL DERIVATIVES AS MEDICAMENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1992-04-16 | — | — | WO | disclosed |