SCHEMBL9701342

SCHEMBL9701342

CC(=O)CC(=O)c1ccc2ccc(S(C)(=O)=O)cc2c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.45
KDM4E B2RXH2 1/20 0.45
HPGD P15428 1/20 0.45
AKR1C3 P42330 2/20 0.42
AKR1C2 P52895 2/20 0.42
NQO2 P16083 1/20 0.42
MTNR1A P48039 1/20 0.42
MTNR1B P49286 1/20 0.42
ALDH1A1 P00352 1/20 0.42
LMNA P02545 1/20 0.42
HDAC3 O15379 1/20 0.41
HDAC4 P56524 1/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC7 Q8WUI4 1/20 0.41
HDAC2 Q92769 1/20 0.41
HDAC10 Q969S8 1/20 0.41
HDAC11 Q96DB2 1/20 0.41
HDAC8 Q9BY41 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9700367 0.82 GSR (0.57) AKR1C3GSR
SCHEMBL3554845 0.79 AKR1C3 (0.51) GAAKDM4EAKR1C3AKR1C2ALDH1A1
SCHEMBL9700437 0.78 SMN1; SMN2 (0.44) SMN1; SMN2KDM4EHPGDALDH1A1HDAC3
SCHEMBL9699266 0.78 CYP2A6 (0.66) SMN1; SMN2KDM4EHPGDALDH1A1LMNA
SCHEMBL2774094 0.77 SMN1; SMN2 (0.72) SMN1; SMN2KDM4EHPGDALDH1A1HDAC3
SCHEMBL17319528 0.77 AKR1C3 (0.53) GAASMN1; SMN2HPGDAKR1C3AKR1C2
SCHEMBL21258337 0.76 GAA (0.50) GAASMN1; SMN2KDM4EHPGDALDH1A1
SCHEMBL13203351 0.76 AKR1C3 (0.52) GAASMN1; SMN2AKR1C3AKR1C2LMNA
SCHEMBL9700316 0.75 SMN1; SMN2 (0.47) SMN1; SMN2KDM4EHPGDAKR1C3AKR1C2
SCHEMBL9701379 0.74 CYP1A2 (0.61) SMN1; SMN2KDM4EHPGDAKR1C3AKR1C2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5112820-A Vision defects STERLING DRUG INC. (US) 1992-05-12 US disclosed
US-5109135-A 2- or 3-aminomethyl-4-amino-3,4-dihydro-2H-1,4-benzoxazine intermediates STERLING DRUG INC. (US) 1992-04-28 US disclosed
US-5066803-A Chemical intermediates for analgesics STERLING DRUG INC. (US) 1991-11-19 US disclosed
WO-1990007505-A1 2- AND 3-AMINOMETHYL-6-ARYLCARBONYL-2,3-DIHYDROPYRROLO[1,2,3-de]-1,4-BENZOXAZINES STERLING DRUG INC. (US) 1990-07-12 WO disclosed
US-4939138-A 2- and 3-aminomethyl-6-arylcarbonyl-2,3-dihydropyrrolo(1,2,3-DE)-1,4-benzoxazines STERLING DRUG INC. (US) 1990-07-03 US disclosed