Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4707187 | 0.83 | HAO1 (0.62) | SMN1; SMN2KDM4EHPGDHAO1PLK1 | |
| SCHEMBL9699266 | 0.80 | CYP2A6 (0.66) | SMN1; SMN2KDM4EHPGDCYP2A6PTPN1 | |
| SCHEMBL2774094 | 0.80 | SMN1; SMN2 (0.72) | SMN1; SMN2KDM4EHPGDPTPN1NPC1 | |
| SCHEMBL10414901 | 0.78 | SMN1; SMN2 (0.49) | SMN1; SMN2KDM4EHPGDHAO1PLK1 | |
| SCHEMBL3556153 | 0.78 | KDM4E (0.50) | SMN1; SMN2KDM4EHPGDPLK1CYP2A6 | |
| SCHEMBL10415427 | 0.77 | PTPN1 (0.64) | SMN1; SMN2KDM4EHPGDHAO1PLK1 | |
| SCHEMBL9701379 | 0.76 | CYP1A2 (0.61) | SMN1; SMN2KDM4EHPGDCYP2A6AKR1C3 | |
| SCHEMBL9701342 | 0.75 | GAA (0.46) | SMN1; SMN2KDM4EHPGDCYP2A6NQO2 | |
| SCHEMBL28482006 | 0.75 | CYP2A6 (0.58) | SMN1; SMN2KDM4EHPGDCYP2A6PTPN1 | |
| SCHEMBL9700437 | 0.74 | SMN1; SMN2 (0.44) | SMN1; SMN2KDM4EHPGDCYP2A6PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112820-A | Vision defects | STERLING DRUG INC. (US) | 1992-05-12 | — | — | US | disclosed |
| US-5109135-A | 2- or 3-aminomethyl-4-amino-3,4-dihydro-2H-1,4-benzoxazine intermediates | STERLING DRUG INC. (US) | 1992-04-28 | — | — | US | disclosed |
| US-5066803-A | Chemical intermediates for analgesics | STERLING DRUG INC. (US) | 1991-11-19 | — | — | US | disclosed |
| WO-1990007505-A1 | 2- AND 3-AMINOMETHYL-6-ARYLCARBONYL-2,3-DIHYDROPYRROLO[1,2,3-de]-1,4-BENZOXAZINES | STERLING DRUG INC. (US) | 1990-07-12 | — | — | WO | disclosed |