Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.34 |
| ▸ | DRD2 | P14416 | 6/20 | 0.34 |
| ▸ | HTR2A | P28223 | 5/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.31 |
| ▸ | HTR1A | P08908 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9025209 | 0.87 | DRD2 (0.43) | HTR2CDRD2HTR2AHTR1A | |
| Hydrochloric Acid SCHEMBL9024139 | 0.86 | DRD2 (0.43) | HTR2CDRD2HTR2AHTR1A | |
| Hydrochloric Acid SCHEMBL9700480 | 0.85 | HTR2C (0.43) | HTR2CDRD2HTR2AKDM4E | |
| SCHEMBL9689077 | 0.79 | DRD2 (0.43) | HTR2CDRD2HTR2AHTR1A | |
| SCHEMBL9700487 | 0.78 | HTR2C (0.43) | HTR2CDRD2HTR2AHTR1AKDM4E | |
| SCHEMBL9445210 | 0.76 | DCTPP1 (0.39) | DRD2HTR2AHTR1A | |
| SCHEMBL9023838 | 0.75 | HTR2C (0.55) | HTR2CDRD2HTR2AKDM4E | |
| SCHEMBL9023761 | 0.75 | MAPK10 (0.40) | DRD2 | |
| Hydrochloric Acid SCHEMBL9023939 | 0.75 | HTR2C (0.54) | HTR2CDRD2HTR2AKDM4E | |
| SCHEMBL9689848 | 0.74 | NR4A2 (0.41) | HTR2CDRD2HTR2AHTR1AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0474012-A1 | 6,7-Dihydro-3-phenyl-1,2-benzisoxazol-4(5H)-ones and -ols, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-03-11 | — | — | EP | claimed |