Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 4/20 | 0.40 |
| ▸ | DRD4 | P21917 | 3/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9701642 | 0.88 | HTR2C (0.43) | HTR2CMAPTPOLBDRD2DRD4 | |
| SCHEMBL9024113 | 0.88 | HTR2C (0.54) | HTR2CPOLBDRD2DRD4DRD3 | |
| SCHEMBL9687660 | 0.82 | HTR2C (0.56) | HTR2CDRD2DRD4DRD3SIGMAR1 | |
| Hydrochloric Acid SCHEMBL9023938 | 0.81 | HTR2C (0.56) | HTR2CDRD2DRD4DRD3SIGMAR1 | |
| SCHEMBL9474916 | 0.81 | HTR2C (0.53) | HTR2CMAPTDRD2DRD4SIGMAR1 | |
| Hydrochloric Acid SCHEMBL9445171 | 0.80 | HTR2C (0.53) | HTR2CMAPTDRD2DRD4SIGMAR1 | |
| SCHEMBL9701571 | 0.78 | HTR2C (0.34) | HTR2CDRD2HTR1AKDM4EHTR2A | |
| SCHEMBL9688546 | 0.78 | HTR2C (0.56) | HTR2CDRD2DRD4DRD3SIGMAR1 | |
| SCHEMBL9024747 | 0.77 | HTR2C (0.57) | HTR2CDRD2DRD4DRD3SIGMAR1 | |
| Hydrochloric Acid SCHEMBL9023951 | 0.77 | HTR2C (0.55) | HTR2CDRD2DRD4DRD3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0474012-A1 | 6,7-Dihydro-3-phenyl-1,2-benzisoxazol-4(5H)-ones and -ols, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-03-11 | — | — | EP | disclosed |