Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 2/20 | 0.70 |
| ▸ | ACMSD | Q8TDX5 | 3/20 | 0.59 |
| ▸ | MGLL | Q99685 | 2/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | DHODH | Q02127 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | ESR1 | P03372 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | HNF4A | P41235 | 2/20 | 0.52 |
| ▸ | DHFR | P00374 | 1/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.52 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.52 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.52 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL11165825 | 0.94 | KMO (0.61) | KMOACMSDMGLLHDAC8HDAC4 | |
| SCHEMBL2731883 | 0.87 | ALDH1A1 (0.69) | KMOACMSDMGLLHDAC8HDAC4 | |
| Biphenyl SCHEMBL11687528 | 0.87 | ALDH1A1 (0.69) | KMOACMSDMGLLHDAC8HDAC4 | |
| Biphenyl SCHEMBL750993 | 0.87 | ALDH1A1 (0.69) | KMOALDH1A1 | |
| Biphenyl SCHEMBL377457 | 0.87 | ALDH1A1 (0.69) | KMOALDH1A1 | |
| SCHEMBL2401076 | 0.87 | ALDH1A1 (0.69) | KMOACMSDMGLLHDAC8HDAC4 | |
| Biphenyl SCHEMBL190337 | 0.87 | ALDH1A1 (0.69) | KMOALDH1A1 | |
| Biphenyl SCHEMBL1839538 | 0.87 | ALDH1A1 (0.69) | KMOALDH1A1 | |
| Biphenyl SCHEMBL1396421 | 0.87 | ALDH1A1 (0.69) | KMOALDH1A1 | |
| SCHEMBL31734209 | 0.87 | ALDH1A1 (0.69) | KMOACMSDMGLLHDAC8HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5145939-A | With copolymers of bisphenol a; solvent resistance | GENERAL ELECTRIC COMPANY (US) | 1992-09-08 | — | — | US | claimed |
| US-5145939-A | With copolymers of bisphenol a; solvent resistance | GENERAL ELECTRIC COMPANY (US) | 1992-09-08 | — | — | US | disclosed |