Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NOS1 | P29475 | 1/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.44 |
| ▸ | TUBB | P07437 | 1/20 | 0.44 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.44 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.44 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.44 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28964166 | 0.79 | MAPT (0.59) | MAPTGAAKDM4EALDH1A1TDP1 | |
| SCHEMBL30301281 | 0.79 | MAPT (0.59) | MAPTGAAKDM4EALDH1A1TDP1 | |
| SCHEMBL9702101 | 0.78 | MAPT (0.57) | MAPTGAAKDM4EALDH1A1TDP1 | |
| SCHEMBL8357999 | 0.76 | MAPT (0.63) | MAPTGAAKDM4EALDH1A1TDP1 | |
| SCHEMBL6798344 | 0.75 | CACNA1B (0.52) | MAPTGAAKDM4EALDH1A1RAB9A | |
| SCHEMBL13636688 | 0.75 | MAPT (0.65) | MAPTGAAKDM4EALDH1A1TDP1 | |
| SCHEMBL17602294 | 0.74 | MAPT (0.43) | MAPTGAAKDM4EALDH1A1TDP1 | |
| SCHEMBL2894310 | 0.73 | MAPT (0.44) | MAPTGAAKDM4EALDH1A1TDP1 | |
| SCHEMBL6733668 | 0.73 | ALDH1A1 (0.59) | MAPTGAAKDM4EALDH1A1RAB9A | |
| SCHEMBL17782436 | 0.73 | MAPT (0.61) | MAPTGAAKDM4EALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0221677-B1 | P-AMINOPHENOLS, DERIVATIVES THEREOF AND USE FOR MANUFACTURE OF A MEDICAMENT | E.R. Squibb & Sons, Inc. (US) | 1992-09-09 | — | — | EP | disclosed |
| EP-0221677-A2 | p-Aminophenols, derivatives thereof and use for manufacture of a medicament | E.R. Squibb & Sons, Inc. (US) | 1987-05-13 | — | — | EP | disclosed |