Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.34 |
| ▸ | CPT1A | P50416 | 3/20 | 0.33 |
| ▸ | CPT2 | P23786 | 2/20 | 0.33 |
| ▸ | SPR | P35270 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | F2R | P25116 | 1/20 | 0.32 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10419845 | 0.85 | HSD11B1 (0.39) | HCRTR1HCRTR2HSD11B1CPT1ACPT2 | |
| SCHEMBL10419847 | 0.84 | EPHX2 (0.41) | HSD11B1SMYD3GABRA1GABRB2GABRA6 | |
| SCHEMBL9702691 | 0.79 | SCN9A (0.37) | GABRA1GABRB2 | |
| SCHEMBL9704984 | 0.75 | CA1 (0.36) | — | |
| SCHEMBL9703140 | 0.75 | GABRA1 (0.37) | GABRA1GABRB2GABRA6 | |
| SCHEMBL9703179 | 0.72 | GABRA1 (0.37) | GABRA1GABRB2GABRA6 | |
| SCHEMBL10419467 | 0.70 | HSD11B1 (0.36) | HSD11B1 | |
| SCHEMBL3696393 | 0.70 | CNR1 (0.39) | HCRTR1HCRTR2HSD11B1SMYD3SPR | |
| SCHEMBL18711263 | 0.70 | SMO (0.45) | HCRTR1HCRTR2HSD11B1SMYD3SPR | |
| Oxalic Acid SCHEMBL9702934 | 0.69 | USP7 (0.49) | HCRTR1HCRTR2HSD11B1CPT1ACPT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0259621-B1 | PIPERIDINE COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1992-11-25 | — | — | EP | disclosed |
| US-4933353-A | ALZHEIMER*S DISEASE | A/S FERROSAN (DE) | 1990-06-12 | — | — | US | disclosed |
| US-4837241-A | TREATMENT OF ALZEHEIMER*S DISEASE | A/S FERROSAN (DK) | 1989-06-06 | — | — | US | disclosed |
| EP-0259621-A2 | Piperidine compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1988-03-16 | — | — | EP | disclosed |