Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.81 |
| ▸ | DRD3 | P35462 | 2/20 | 0.81 |
| ▸ | DRD4 | P21917 | 1/20 | 0.81 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9703331 | 0.90 | DRD2 (1.00) | DRD2DRD3DRD4ADRA1D | |
| SCHEMBL9703158 | 0.79 | DRD2 (0.81) | DRD2DRD3DRD4ADRA1D | |
| SCHEMBL9703250 | 0.79 | DRD2 (0.79) | DRD2DRD3DRD4CYP2D6 | |
| SCHEMBL9703912 | 0.79 | DRD2 (0.79) | DRD2DRD3DRD4 | |
| SCHEMBL7700873 | 0.78 | ADRA1D (0.65) | DRD2DRD3DRD4ADRA1D | |
| SCHEMBL9705545 | 0.77 | DRD2 (0.64) | DRD2DRD3DRD4 | |
| SCHEMBL9703684 | 0.77 | DRD2 (0.75) | DRD2DRD3DRD4 | |
| SCHEMBL14306777 | 0.75 | ADRA1D (0.80) | ADRA1DCYP2D6 | |
| SCHEMBL9703793 | 0.74 | DRD2 (0.56) | DRD2DRD3DRD4 | |
| Hydrochloric Acid SCHEMBL7259157 | 0.71 | ADRA1D (0.90) | ADRA1DCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992012977-A1 | SUBSTITUTED INDOLES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-08-06 | — | — | WO | claimed |
| WO-1992012977-A1 | SUBSTITUTED INDOLES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-08-06 | — | — | WO | disclosed |
| US-5124332-A | Dopaminergic agents, hypotensive agents | WARNER-LAMBERT COMPANY (US) | 1992-06-23 | — | — | US | disclosed |