Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.75 |
| ▸ | DRD3 | P35462 | 2/20 | 0.75 |
| ▸ | DRD4 | P21917 | 1/20 | 0.75 |
| ▸ | HTR1A | P08908 | 3/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9703912 | 0.87 | DRD2 (0.79) | DRD2DRD3DRD4HTR1ASIGMAR1 | |
| SCHEMBL9703250 | 0.87 | DRD2 (0.79) | DRD2DRD3DRD4HTR1A | |
| SCHEMBL9703331 | 0.86 | DRD2 (1.00) | DRD2DRD3DRD4 | |
| SCHEMBL946686 | 0.78 | LMNA (0.59) | DRD2DRD3DRD4HTR1A | |
| SCHEMBL9703330 | 0.77 | DRD2 (0.81) | DRD2DRD3DRD4 | |
| SCHEMBL9703158 | 0.77 | DRD2 (0.81) | DRD2DRD3DRD4HTR1A | |
| SCHEMBL14761650 | 0.73 | HTR1A (1.00) | DRD2DRD3DRD4HTR1ASIGMAR1 | |
| SCHEMBL19823060 | 0.73 | DRD2 (0.66) | DRD2DRD3DRD4HTR1A | |
| SCHEMBL9703913 | 0.73 | DRD2 (0.66) | DRD2DRD3DRD4HTR1A | |
| SCHEMBL25758273 | 0.72 | SLC6A4 (0.66) | DRD2HTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992012977-A1 | SUBSTITUTED INDOLES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-08-06 | — | — | WO | claimed |
| WO-1992012977-A1 | SUBSTITUTED INDOLES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-08-06 | — | — | WO | disclosed |
| US-5124332-A | Dopaminergic agents, hypotensive agents | WARNER-LAMBERT COMPANY (US) | 1992-06-23 | — | — | US | disclosed |