Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 13/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 2/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9703536 | 0.86 | TP53 (0.42) | AMY1APDE3BPDE3APDE4APDE4B | |
| SCHEMBL9703372 | 0.84 | AMY1A (0.38) | AMY1APDE3BPDE3APDE4APDE4B | |
| SCHEMBL10373752 | 0.82 | PDE3B (0.48) | AMY1APDE3BPDE3APDE4APDE4B | |
| SCHEMBL9703649 | 0.79 | AMY1A (0.43) | AMY1APDE3BPDE3APDE5ATP53 | |
| SCHEMBL10852513 | 0.78 | AMY1A (0.40) | AMY1APDE3BPDE3APDE5ATP53 | |
| SCHEMBL10558256 | 0.78 | AMY1A (0.39) | AMY1APDE3BPDE3APDE5APDE2A | |
| SCHEMBL9703362 | 0.77 | PDE5A (0.37) | AMY1APDE3BPDE3APDE4APDE4B | |
| SCHEMBL10697003 | 0.77 | AMY1A (0.45) | AMY1APDE3BPDE3APDE4APDE4B | |
| SCHEMBL9703428 | 0.77 | PDE3B (0.41) | AMY1APDE3BPDE3APDE4APDE4B | |
| SCHEMBL9702924 | 0.76 | AMY1A (0.41) | AMY1APDE3BPDE3APDE5ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116843-A | Anticoagulants, hypotensive agents and cardiovascular disorder | BOEHRINGER MANNHEIM GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| EP-0275888-A2 | Tricyclic benzimidazoles, process for their preparation and use as medicaments | Roche Diagnostics GmbH (DE) | 1988-07-27 | — | — | EP | disclosed |