Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 11/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9703536 | 0.87 | TP53 (0.42) | AMY1APDE3BPDE3APDE4APDE4B | |
| SCHEMBL9703453 | 0.84 | AMY1A (0.37) | AMY1APDE3BPDE3APDE4APDE4B | |
| SCHEMBL10373868 | 0.81 | PDE3B (0.49) | AMY1APDE3BPDE3APDE4APDE4B | |
| SCHEMBL10697003 | 0.78 | AMY1A (0.45) | AMY1APDE3BPDE3APDE4APDE4B | |
| SCHEMBL10557582 | 0.77 | AMY1A (0.39) | AMY1APDE3BPDE3APDE5ACHEK2 | |
| SCHEMBL9703298 | 0.77 | PDE5A (0.38) | AMY1APDE3BPDE3APDE4APDE4B | |
| SCHEMBL9703397 | 0.77 | NPC1 (0.50) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10849719 | 0.76 | AMY1A (0.41) | AMY1APDE3BPDE3APDE5ACHEK2 | |
| SCHEMBL11301435 | 0.74 | AMY1A (0.38) | AMY1APDE3BPDE3APDE5ACHEK2 | |
| SCHEMBL9703459 | 0.73 | PDE4A (0.50) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116843-A | Anticoagulants, hypotensive agents and cardiovascular disorder | BOEHRINGER MANNHEIM GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| EP-0275888-A2 | Tricyclic benzimidazoles, process for their preparation and use as medicaments | Roche Diagnostics GmbH (DE) | 1988-07-27 | — | — | EP | disclosed |