Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | AMY1A | P0DUB6 | 4/20 | 0.32 |
| ▸ | KDR | P35968 | 2/20 | 0.30 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | METAP1 | P53582 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10477969 | 0.81 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10557598 | 0.76 | AMY1A (0.34) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL9703397 | 0.76 | NPC1 (0.50) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10697003 | 0.75 | AMY1A (0.45) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL9703307 | 0.75 | PDE4A (0.34) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL9703536 | 0.75 | TP53 (0.42) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL9703459 | 0.74 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL9378683 | 0.74 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL9703633 | 0.71 | PDGFRB (0.36) | PDE3BPDE3AAMY1AKDRPDGFRB | |
| SCHEMBL9703372 | 0.71 | AMY1A (0.38) | PDE4APDE4BPDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116843-A | Anticoagulants, hypotensive agents and cardiovascular disorder | BOEHRINGER MANNHEIM GMBH (DE) | 1992-05-26 | — | — | US | disclosed |