Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | TOP2A | P11388 | 4/20 | 0.32 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 4/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 6/20 | 0.32 |
| ▸ | CNR1 | P21554 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9703892 | 0.87 | TOP2A (0.40) | KDM4ESMN1; SMN2CYP1A2KMT2AALDH1A1 | |
| SCHEMBL9704619 | 0.78 | BAZ2B (0.40) | KDM4EKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL9703818 | 0.77 | KDM4E (0.48) | KDM4ESMN1; SMN2CYP1A2KMT2AALDH1A1 | |
| SCHEMBL9703781 | 0.76 | ADRB2 (0.46) | KDM4ESMN1; SMN2CYP1A2KMT2AALDH1A1 | |
| SCHEMBL9703785 | 0.75 | KDM4E (0.52) | KDM4ESMN1; SMN2CYP1A2KMT2AALDH1A1 | |
| SCHEMBL10401667 | 0.74 | KDM4E (0.55) | KDM4EALDH1A1LMNAHPGDMAPK1 | |
| SCHEMBL9703924 | 0.71 | KDM4E (0.45) | KDM4EALDH1A1MAPTLMNAHPGD | |
| SCHEMBL9703601 | 0.70 | KDM4E (0.55) | KDM4ESMN1; SMN2CYP1A2ALDH1A1TOP2A | |
| SCHEMBL9704598 | 0.69 | STAT3 (0.50) | KDM4ESMN1; SMN2CYP1A2KMT2AALDH1A1 | |
| SCHEMBL9705531 | 0.68 | HPGD (0.38) | KDM4EKMT2AMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0203795-B1 | Benzo [i,j] quinolizine-2-carboxylic acid derivatives, the salts and their hydrates, pharmaceutical compositions thereof, and process for preparing the same | TOKYO TANABE COMPANY LIMITED (JP) | 1992-07-29 | — | — | EP | disclosed |
| EP-0203795-A2 | Benzo [i,j] quinolizine-2-carboxylic acid derivatives, the salts and their hydrates, pharmaceutical compositions thereof, and process for preparing the same | TOKYO TANABE COMPANY LIMITED (JP) | 1986-12-03 | — | — | EP | disclosed |