Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 5/20 | 0.40 |
| ▸ | TOP2B | Q02880 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | ALB | P02768 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9703781 | 0.89 | ADRB2 (0.46) | TOP2ATOP2BKDM4ESMN1; SMN2CYP1A2 | |
| SCHEMBL9703785 | 0.88 | KDM4E (0.52) | TOP2ATOP2BKDM4ESMN1; SMN2CYP1A2 | |
| SCHEMBL9703759 | 0.87 | KDM4E (0.35) | TOP2ATOP2BKDM4ESMN1; SMN2CYP1A2 | |
| SCHEMBL10401667 | 0.82 | KDM4E (0.55) | KDM4ELMNAALDH1A1HPGDHSD17B10 | |
| SCHEMBL9703924 | 0.79 | KDM4E (0.45) | KDM4ELMNAALDH1A1HPGDHSD17B10 | |
| SCHEMBL9704598 | 0.78 | STAT3 (0.50) | TOP2ATOP2BKDM4ESMN1; SMN2CYP1A2 | |
| SCHEMBL9704619 | 0.78 | BAZ2B (0.40) | KDM4ELMNAKMT2AALDH1A1HPGD | |
| SCHEMBL9703378 | 0.78 | ADRB2 (0.45) | TOP2ATOP2BKDM4ELMNAKMT2A | |
| SCHEMBL9703818 | 0.77 | KDM4E (0.48) | TOP2ATOP2BKDM4ESMN1; SMN2CYP1A2 | |
| SCHEMBL5704356 | 0.75 | GSK3B (0.53) | TOP2ATOP2BKDM4ELMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0203795-B1 | Benzo [i,j] quinolizine-2-carboxylic acid derivatives, the salts and their hydrates, pharmaceutical compositions thereof, and process for preparing the same | TOKYO TANABE COMPANY LIMITED (JP) | 1992-07-29 | — | — | EP | disclosed |
| US-4720495-A | Benzo[ij]quinolizine-2-carboxylic acids useful for treating bacterial infection | TOKYO TANABE CO. LIMITED (JP) | 1988-01-19 | — | — | US | disclosed |
| EP-0203795-A2 | Benzo [i,j] quinolizine-2-carboxylic acid derivatives, the salts and their hydrates, pharmaceutical compositions thereof, and process for preparing the same | TOKYO TANABE COMPANY LIMITED (JP) | 1986-12-03 | — | — | EP | disclosed |