Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 14/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 9/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10227646 | 0.78 | NPC1 (0.42) | NPC1RAB9AKDM4EMAPTDAO | |
| SCHEMBL10227647 | 0.75 | FLT3 (0.48) | NPC1RAB9AKDM4EMAPTDAO | |
| SCHEMBL19746393 | 0.75 | NPC1 (0.46) | CDK9CCNT1NPC1RAB9A | |
| SCHEMBL10984508 | 0.72 | HTR2A (0.54) | CDK9CCNT1KDM4EHPGD | |
| SCHEMBL2522495 | 0.71 | CDK9 (0.47) | CDK9CCNT1RAB9AKDM4EMAPT | |
| SCHEMBL2522501 | 0.71 | CDK9 (0.47) | CDK9CCNT1RAB9AKDM4EMAPT | |
| SCHEMBL9703865 | 0.71 | SLC6A4 (0.60) | NPC1RAB9AKDM4EMAPTHSD17B10 | |
| SCHEMBL31181951 | 0.69 | RAB9A (0.50) | NPC1RAB9AKDM4EMAPTHPGD | |
| SCHEMBL2085643 | 0.69 | RAB9A (0.50) | NPC1RAB9AKDM4EMAPTHPGD | |
| SCHEMBL1174412 | 0.68 | RAB9A (0.49) | NPC1RAB9AKDM4EMAPTDAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992012977-A1 | SUBSTITUTED INDOLES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-08-06 | — | — | WO | disclosed |
| US-5124332-A | Dopaminergic agents, hypotensive agents | WARNER-LAMBERT COMPANY (US) | 1992-06-23 | — | — | US | disclosed |