Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | GPR3 | P46089 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 2/20 | 0.31 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9149214 | 0.78 | EPHX2 (0.40) | EPHX2CYP1A2CYP2D6HTR2AGPR3 | |
| SCHEMBL18761143 | 0.76 | HTR2A (0.34) | CYP1A2CYP2D6HTR2AGPR3 | |
| SCHEMBL19648931 | 0.68 | L3MBTL1 (0.36) | — | |
| SCHEMBL1989836 | 0.63 | S100A4 (0.53) | CYP1A2HTR2A | |
| Hydrochloric Acid SCHEMBL4634094 | 0.63 | GPR3 (0.35) | EPHX2CYP1A2CYP2D6HTR2AGPR3 | |
| SCHEMBL18719217 | 0.63 | HTR2A (0.36) | SLC6A2SLC6A3SLC6A4HTR2AKDM1A | |
| SCHEMBL15129175 | 0.63 | S100A4 (0.53) | CYP1A2HTR2A | |
| SCHEMBL14855914 | 0.63 | S100A4 (0.53) | CYP1A2HTR2A | |
| SCHEMBL4748664 | 0.63 | HTR2A (0.58) | HTR2AKDM1A | |
| SCHEMBL24399524 | 0.62 | HTR2A (0.43) | CYP1A2SLC6A2SLC6A3SLC6A4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0469683-A1 | Derivatives of 4-amino-1-methyltetralins, their preparation and their application in therapy | LABORATOIRES LUCIEN, Société Anonyme : (FR) | 1992-02-05 | — | — | EP | disclosed |