Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | NPBWR1 | P48145 | 4/20 | 0.52 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.49 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11371536 | 0.91 | MAPT (0.48) | ALDH1A1MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2449514 | 0.84 | KCNJ1 (0.57) | KCNJ1KDM4ENPBWR1RIPK1KDR | |
| SCHEMBL9704323 | 0.83 | GAA (0.53) | ALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL6377630 | 0.83 | ALDH1A1 (0.51) | KDM4ECYP1A2ALDH1A1MEN1KMT2A | |
| SCHEMBL6602465 | 0.81 | CHEK1 (0.53) | — | |
| SCHEMBL6377225 | 0.81 | SIRT2 (0.56) | ALDH1A1TDP1 | |
| SCHEMBL3995236 | 0.80 | ALDH1A1 (0.53) | KDM4ECYP1A2ALDH1A1MAPTNPC1 | |
| SCHEMBL6605386 | 0.80 | CHEK1 (0.49) | — | |
| SCHEMBL11376992 | 0.80 | GABRA2 (0.43) | ALDH1A1MAPTNPC1LMNA | |
| SCHEMBL6608335 | 0.80 | CHEK1 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992011245-A1 | 2-ACYLAMIDO DERIVATIVES OF 3,4-DIHYDRO-3-OXO-QUINOXALINE HAVING PHARMACEUTICAL ACTIVITY | WARNER-LAMBERT COMPANY (US) | 1992-07-09 | — | — | WO | disclosed |