Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 2/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.53 |
| ▸ | ACMSD | Q8TDX5 | 3/20 | 0.51 |
| ▸ | HNF4A | P41235 | 3/20 | 0.50 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.50 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.50 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.50 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.50 |
| ▸ | KMO | O15229 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | GSTA1 | P08263 | 1/20 | 0.46 |
| ▸ | DHFR | P00374 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8778337 | 0.94 | HDAC4 (0.53) | HDAC4HDAC2HDAC8ACMSDHNF4A | |
| SCHEMBL10338434 | 0.94 | HDAC4 (0.53) | HDAC4HDAC2HDAC8ACMSDHNF4A | |
| Bicarbonate SCHEMBL27723911 | 0.88 | HNF4A (0.62) | HDAC4HDAC2HDAC8HNF4AALDH1A1 | |
| SCHEMBL9973586 | 0.86 | HPGD (0.52) | HDAC4HDAC2HDAC8HNF4AALDH1A1 | |
| Bicarbonate SCHEMBL27836063 | 0.85 | HNF4A (0.58) | HDAC4HDAC2HDAC8HNF4AALDH1A1 | |
| SCHEMBL13368747 | 0.84 | HPGD (0.60) | HDAC4HDAC2HDAC8HNF4AALDH1A1 | |
| Biphenyl SCHEMBL25432905 | 0.84 | ALDH1A1 (0.65) | HDAC4HDAC2HDAC8HNF4AALDH1A1 | |
| SCHEMBL9767873 | 0.83 | HPGD (0.54) | HDAC4HDAC2HDAC8ACMSDHNF4A | |
| SCHEMBL22310170 | 0.83 | HDAC4 (0.50) | HDAC4HDAC2HDAC8ACMSDHNF4A | |
| Oxalic Acid SCHEMBL28580275 | 0.82 | HNF4A (0.60) | HDAC4HDAC2HDAC8HNF4AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5145939-A | With copolymers of bisphenol a; solvent resistance | GENERAL ELECTRIC COMPANY (US) | 1992-09-08 | — | — | US | disclosed |