SCHEMBL9704426

SCHEMBL9704426

N#Cc1nc(C(Cl)=NNc2c(Cl)cc(C(F)(F)F)cc2Cl)[nH]c1C#N

nearest known ligand 0.32

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.32
TDP1 Q9NUW8 1/20 0.32
GABRP O00591 1/20 0.31
GABRD O14764 1/20 0.31
NR1I2 O75469 1/20 0.31
LMNA P02545 1/20 0.31
CYP3A4 P08684 1/20 0.31
GABRA1 P14867 1/20 0.31
GABRB1 P18505 1/20 0.31
GABRG2 P18507 1/20 0.31
GABRB3 P28472 1/20 0.31
GABRA5 P31644 1/20 0.31
GABRA3 P34903 1/20 0.31
GABRA2 P47869 1/20 0.31
GABRB2 P47870 1/20 0.31
GABRA4 P48169 1/20 0.31
GABRE P78334 1/20 0.31
GABRA6 Q16445 1/20 0.31
GABRG1 Q8N1C3 1/20 0.31
GABRG3 Q99928 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9704419 1.00 SMN1; SMN2 (0.32) SMN1; SMN2TDP1GABRPGABRDNR1I2
SCHEMBL9703419 0.88 SMN1; SMN2 (0.33) SMN1; SMN2TDP1GABRPGABRDNR1I2
SCHEMBL9703425 0.88 SMN1; SMN2 (0.33) SMN1; SMN2TDP1GABRPGABRDNR1I2
SCHEMBL9704423 0.74 MRGPRX4 (0.33)
SCHEMBL7744114 0.72 KIF11 (0.39) SMN1; SMN2GABRPGABRDGABRA1GABRB1
SCHEMBL7744112 0.72 KIF11 (0.39) SMN1; SMN2GABRPGABRDGABRA1GABRB1
SCHEMBL9215555 0.71 NPBWR1 (0.38) SMN1; SMN2TDP1GABRPGABRDNR1I2
SCHEMBL6258551 0.68 RAPGEF3 (0.38) SMN1; SMN2TDP1LMNAALDH1A1GAA
SCHEMBL9703422 0.68 MRGPRX4 (0.34) SMN1; SMN2ALDH1A1HTT
SCHEMBL5743661 0.67 GAA (0.37) SMN1; SMN2TDP1LMNAALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1992013451-A1 IMIDAZOLE PESTICIDES SCHERING AGROCHEMICALS LIMITED (GB) 1992-08-20 WO disclosed