Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 6/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.54 |
| ▸ | HTR1A | P08908 | 3/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.51 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | SCN1A | P35498 | 1/20 | 0.51 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.51 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9703876 | 0.90 | CHRM2 (0.56) | CYP2D6CHRM2CHRM1KCNH2HTR1A | |
| SCHEMBL14744149 | 0.83 | CHRM2 (0.54) | CYP2D6CHRM2CHRM1KCNH2HTR1A | |
| SCHEMBL28307561 | 0.77 | CHRM2 (0.51) | CYP2D6CHRM2CHRM1KCNH2HTR1A | |
| SCHEMBL12264131 | 0.74 | KIF11 (0.74) | KIF11KMT2AMEN1TSHRTDP1 | |
| SCHEMBL16176745 | 0.74 | HTR7 (0.49) | HTR1ASIGMAR1KDM4EMAPK1KMT2A | |
| SCHEMBL8296146 | 0.73 | DRD2 (0.61) | HTR1ADRD2DRD3 | |
| SCHEMBL6699352 | 0.73 | CHRM2 (0.74) | CYP2D6CHRM2CHRM1KCNH2HTR1A | |
| SCHEMBL8673780 | 0.73 | POLB (0.59) | DPP7SIGMAR1DRD3KMT2AMEN1 | |
| SCHEMBL11610162 | 0.73 | CHRM2 (0.74) | CYP2D6CHRM2CHRM1KCNH2HTR1A | |
| Hydrochloric Acid SCHEMBL11093613 | 0.71 | POLB (0.58) | LMNADPP7SIGMAR1DRD3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0480794-A1 | 2-Aminopyrimidine-4-carboxamide derivatives, their preparation and therapeutic use | SYNTHELABO (FR) | 1992-04-15 | — | — | EP | disclosed |