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Sugi Predict / Compounds / Tyrosine

Tyrosine

Tyrosine

SCHEMBL9705162

CC[C@H](C)[C@H](N)C(=O)O.C[C@H](N)C(=O)O.N=C(N)NCCC[C@H](N)C(=O)O.NCC(=O)O.NCC(=O)O.N[C@@H](Cc1ccc(O)cc1)C(=O)O.N[C@@H](Cc1ccccc1)C(=O)O.O=C(O)[C@@H]1CCCN1

nearest known ligand 0.38

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACE

The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ NPY4R P50391 11/20 0.38
▸ NPY1R P25929 6/20 0.38
▸ NPY2R P49146 4/20 0.38
▸ NPY5R Q15761 4/20 0.38
▸ REN P00797 1/20 0.37
▸ MAPK8 P45983 1/20 0.34
▸ MAPK9 P45984 1/20 0.34
▸ MAPK10 P53779 1/20 0.34
▸ OPRM1 P35372 2/20 0.34
▸ OPRD1 P41143 2/20 0.34
▸ CTSC P53634 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Arginine SCHEMBL7576309 0.93 REN (0.38) NPY4RNPY1RNPY2RNPY5RREN
Arginine SCHEMBL9702449 0.91 KEAP1 (0.37) RENMAPK8MAPK9MAPK10CTSC
Arginine SCHEMBL28022079 0.90 REN (0.39) RENMAPK8MAPK9MAPK10
Arginine SCHEMBL28199097 0.90 REN (0.39) RENMAPK8MAPK9MAPK10
Arginine SCHEMBL11147102 0.89 CTSC (0.37) NPY4RNPY1RNPY2RNPY5RREN
Tyrosine SCHEMBL29274248 0.88 NPY4R (0.40) NPY4RNPY1RNPY2RNPY5RREN
Arginine SCHEMBL3656565 0.88 CTSC (0.41) NPY4RNPY1RNPY2RNPY5RREN
Arginine SCHEMBL17982370 0.87 PRCP (0.36) MAPK8MAPK9MAPK10
Arginine SCHEMBL2501111 0.87 PRCP (0.36) MAPK8MAPK9MAPK10
Tyrosine SCHEMBL29246488 0.87 NPY4R (0.40) NPY4RNPY1RNPY2RNPY5R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1992014489-A1 POLIOVIRUS-BASED VACCINES REPLIGEN CORPORATION (US) 1992-09-03 — — WO claimed
WO-1992014489-A1 POLIOVIRUS-BASED VACCINES REPLIGEN CORPORATION (US) 1992-09-03 — — WO disclosed