Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | POLA1 | P09884 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9704936 | 0.83 | POLA1 (0.41) | POLA1 | |
| SCHEMBL8657853 | 0.81 | ATM (0.42) | LMNAMEN1KMT2AHDAC3HTT | |
| SCHEMBL9705991 | 0.81 | PARP1 (0.47) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL11267581 | 0.78 | ATM (0.48) | LMNAHDAC3HDAC1HDAC2RAB9A | |
| SCHEMBL8652065 | 0.73 | DRD2 (0.46) | MEN1POLBKMT2AHTTALDH1A1 | |
| SCHEMBL8653854 | 0.72 | RAB9A (0.50) | HDAC3ALDH1A1MAPTHPGDHDAC1 | |
| SCHEMBL9704732 | 0.72 | PAK1 (0.53) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL14786117 | 0.72 | NPSR1 (0.61) | LMNAMEN1POLBKMT2AHTT | |
| SCHEMBL8651538 | 0.72 | ATM (0.48) | HDAC3HDAC1HDAC2RAB9ANPSR1 | |
| SCHEMBL16171 | 0.71 | CDK2 (0.64) | PDE4APDE4BPDE4CPDE4DLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0470543-A1 | Heterocyclic imidazoles, remedies containing them and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-02-12 | — | — | EP | disclosed |