Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | PI4KA | P42356 | 1/20 | 0.38 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.38 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.37 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.37 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 5/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 5/20 | 0.36 |
| ▸ | MERTK | Q12866 | 5/20 | 0.36 |
| ▸ | GAS6 | Q14393 | 5/20 | 0.36 |
| ▸ | AXL | P30530 | 2/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9705994 | 0.83 | PDE4A (0.46) | POLA1 | |
| SCHEMBL9704929 | 0.79 | PARP1 (0.40) | BCHETRPC3TRPC4TRPC5FLT3 | |
| SCHEMBL9704732 | 0.77 | PAK1 (0.53) | POLA1FLT3TYRO3MERTKGAS6 | |
| SCHEMBL9705260 | 0.74 | NOS1 (0.45) | NOS3NOS1NOS2PI4KAPI4K2B | |
| SCHEMBL9706008 | 0.74 | NOS3 (0.40) | NOS3NOS1NOS2PI4KAPI4K2B | |
| SCHEMBL7851163 | 0.72 | PI4KA (0.49) | NOS3NOS1NOS2PI4KAPI4K2B | |
| SCHEMBL29475640 | 0.71 | TYRO3 (0.47) | BCHETRPC3TRPC4TRPC5FLT3 | |
| SCHEMBL9980475 | 0.71 | POLA1 (0.57) | POLA1FLT3TYRO3MERTKGAS6 | |
| SCHEMBL10779057 | 0.70 | POLA1 (0.56) | POLA1FLT3TYRO3MERTKGAS6 | |
| SCHEMBL27573343 | 0.70 | PI4KA (0.45) | NOS3NOS1NOS2PI4KAPI4K2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0470543-A1 | Heterocyclic imidazoles, remedies containing them and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-02-12 | — | — | EP | disclosed |