Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMO | Q99835 | 7/20 | 0.39 |
| ▸ | SCD | O00767 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL966726 | 0.87 | MAPK1 (0.42) | GAAMAPK1SMOSCDLMNA | |
| SCHEMBL966356 | 0.87 | LMNA (0.41) | GAAMAPK1SMOSCDLMNA | |
| SCHEMBL971586 | 0.73 | GRIA1 (0.44) | SMOALDH1A1 | |
| SCHEMBL967522 | 0.71 | ACHE (0.42) | GAAMAPK1LMNAL3MBTL1HPGD | |
| SCHEMBL966583 | 0.69 | ALDH1A1 (0.52) | GAAMAPK1SMOLMNAL3MBTL1 | |
| SCHEMBL965866 | 0.68 | KDM4E (0.39) | MAPK1SMOLMNAL3MBTL1NPC1 | |
| SCHEMBL967547 | 0.68 | AURKA (0.39) | GAALMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3610543 | 0.68 | SMO (0.76) | GAAMAPK1SMOHPGDMEN1 | |
| SCHEMBL968230 | 0.68 | GRIA1 (0.38) | NPC1HPGDTSHRRAB9ASMN1; SMN2 | |
| SCHEMBL967981 | 0.68 | PRMT5 (0.37) | NPC1HPGDTSHRRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110003794-A1 | Naphthyridine Integrase Inhibitors | GSK LLC | 2011-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003794-A1 | Naphthyridine Integrase Inhibitors | PCNA, SAMHD1, NTPCR | GAA 459/4885MAPK1 2224/4885SMO 4609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.