Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2048248 | 0.78 | ADRB1 (0.53) | ALDH1A1KMT2AMEN1MAPTADRB1 | |
| SCHEMBL15462283 | 0.73 | ALDH1A1 (0.61) | ALDH1A1KMT2AMEN1HTTMAPT | |
| SCHEMBL623218 | 0.73 | TDP1 (0.55) | ALDH1A1KMT2AMEN1HTTMAPT | |
| Hydrochloric Acid SCHEMBL7879022 | 0.71 | TDP1 (0.53) | ALDH1A1KMT2AMEN1HTTMAPT | |
| Ammonia Solution, Strong SCHEMBL16053585 | 0.71 | TDP1 (0.53) | ALDH1A1KMT2AMEN1HTTMAPT | |
| SCHEMBL11922737 | 0.71 | ALDH1A1 (0.65) | ALDH1A1KMT2AMEN1HTTMAPT | |
| SCHEMBL8239647 | 0.71 | ADRB1 (0.48) | KMT2AMEN1MAPTPOLBADRB1 | |
| SCHEMBL8263647 | 0.71 | ADRB1 (0.56) | ALDH1A1MAPTADRB1L3MBTL1 | |
| SCHEMBL7038234 | 0.71 | ADRB1 (0.53) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL11169824 | 0.70 | ALDH1A1 (0.49) | ALDH1A1KMT2AMEN1HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0198325-B1 | SUBSTITUTED ANILINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1992-07-15 | — | — | EP | disclosed |
| US-4891429-A | CHEMICAL INTERMEDIATES | HOFFMANN-LA ROCHE INC. (US) | 1990-01-02 | — | — | US | disclosed |
| US-4696930-A | CARDIOVASCULAR DISORDERS, ANTICOAGULANTS | HOFFMANN-LA ROCHE INC. (US) | 1987-09-29 | — | — | US | disclosed |
| EP-0198325-A2 | Substituted aniline derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1986-10-22 | — | — | EP | disclosed |