Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4150146 | 0.83 | PTGS1 (0.55) | KCNH2PKMALDH1A1MAPTCYP11B1 | |
| SCHEMBL8001478 | 0.79 | MMP12 (0.51) | KCNH2ALDH1A1MAPTCYP11B1CYP11B2 | |
| SCHEMBL15887342 | 0.78 | KCNH2 (0.48) | KCNH2PKMALDH1A1MAPTCYP11B1 | |
| SCHEMBL10638229 | 0.77 | MMP12 (0.55) | PKMALDH1A1MAPTLMNAMMP12 | |
| SCHEMBL14565148 | 0.76 | DRD2 (0.47) | KCNH2PKMALDH1A1CYP11B1CYP11B2 | |
| SCHEMBL4143414 | 0.73 | LMNA (0.53) | KCNH2ALDH1A1MAPTLMNAMMP12 | |
| SCHEMBL9706784 | 0.73 | PTGS2 (0.35) | — | |
| SCHEMBL23847802 | 0.73 | KCNH2 (0.46) | KCNH2ALDH1A1CYP11B1CYP11B2KIF11 | |
| SCHEMBL4134290 | 0.73 | MMP12 (0.56) | PKMALDH1A1MAPTLMNAMMP12 | |
| SCHEMBL18500452 | 0.72 | PARP1 (0.51) | KCNH2ALDH1A1MAPTCYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992011256-A1 | PROCESS FOR THE PREPARATION OF BENZOXAZINYLTETRAHYDROPYRIDAZINES | ORTHO PHARMACEUTICAL CORPORATION (US) | 1992-07-09 | — | — | WO | disclosed |