Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 1/20 | 0.62 |
| ▸ | MMP3 | P08254 | 2/20 | 0.62 |
| ▸ | MMP2 | P08253 | 1/20 | 0.62 |
| ▸ | LTA4H | P09960 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | PPARD | Q03181 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9707448 | 0.92 | MMP2 (0.72) | LSSMMP3MMP2LTA4HHDAC1 | |
| SCHEMBL10617099 | 0.91 | L3MBTL1 (0.54) | MMP3MMP2LTA4HALOX5PTGS1 | |
| SCHEMBL10619007 | 0.86 | KCNA3 (0.53) | MMP3MMP2LTA4HALOX5PTGS1 | |
| SCHEMBL10617883 | 0.82 | MMP2 (0.61) | MMP3MMP2LTA4HALOX5PTGS1 | |
| SCHEMBL6744608 | 0.81 | MMP2 (0.54) | MMP3MMP2 | |
| Acetic Acid SCHEMBL10679754 | 0.78 | LSS (0.74) | LSSLTA4HHDAC1HDAC2HDAC3 | |
| SCHEMBL9707360 | 0.78 | ALOX5 (0.72) | MMP3MMP2ALOX5PTGS1PTGS2 | |
| SCHEMBL10679594 | 0.77 | LSS (1.00) | LSSLTA4H | |
| SCHEMBL9707311 | 0.77 | MCHR1 (0.53) | LSSMMP3MMP2LTA4HHDAC1 | |
| SCHEMBL7449433 | 0.77 | MMP2 (1.00) | MMP3MMP2HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0196184-B1 | ARYL DERIVATIVES | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-09-16 | — | — | EP | disclosed |
| US-5036157-A | Hydroxamic acid derivatives, lipoxygenase and cyclooxygenase inhibitors, anticoagulants, antiinflammatory agents | BURROUGHS WELLCOME CO. | 1991-07-30 | — | — | US | disclosed |
| US-4977188-A | Hydroamic acid derivatives | BURROUGHS WELLCOME CO. (US) | 1990-12-11 | — | — | US | disclosed |
| US-4738986-A | CYCLOOXYGENASE, LIDOXYGENASE INHIBITORS | BURROUGHS WELLCOME CO. (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0196184-A2 | Aryl derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-10-01 | — | — | EP | disclosed |