Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 7/20 | 0.72 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.72 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.72 |
| ▸ | MAOB | P27338 | 1/20 | 0.59 |
| ▸ | MMP2 | P08253 | 1/20 | 0.57 |
| ▸ | MMP3 | P08254 | 1/20 | 0.57 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.54 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.54 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10617883 | 0.88 | MMP2 (0.61) | ALOX5PTGS1PTGS2MMP2MMP3 | |
| SCHEMBL9707448 | 0.85 | MMP2 (0.72) | ALOX5PTGS1PTGS2MMP2MMP3 | |
| SCHEMBL9707249 | 0.84 | ALOX5 (1.00) | ALOX5PTGS1PTGS2MAOBNR4A1 | |
| SCHEMBL9707259 | 0.81 | PARP10 (0.56) | ALOX5PTGS1PTGS2MAOBMMP2 | |
| SCHEMBL10617099 | 0.80 | L3MBTL1 (0.54) | ALOX5PTGS1PTGS2MMP2MMP3 | |
| SCHEMBL10619007 | 0.78 | KCNA3 (0.53) | ALOX5PTGS1PTGS2MMP2MMP3 | |
| SCHEMBL2477100 | 0.78 | LTA4H (0.75) | PTGS1PTGS2MAOBEGFR | |
| SCHEMBL10617859 | 0.78 | KDM4E (0.65) | MMP2MMP3 | |
| SCHEMBL9707353 | 0.78 | LSS (0.62) | ALOX5PTGS1PTGS2MMP2MMP3 | |
| SCHEMBL9097342 | 0.77 | EGFR (0.69) | MAOBNR4A1NR4A2NR4A3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0196184-B1 | ARYL DERIVATIVES | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-09-16 | — | — | EP | disclosed |
| US-5036157-A | Hydroxamic acid derivatives, lipoxygenase and cyclooxygenase inhibitors, anticoagulants, antiinflammatory agents | BURROUGHS WELLCOME CO. | 1991-07-30 | — | — | US | disclosed |
| US-4977188-A | Hydroamic acid derivatives | BURROUGHS WELLCOME CO. (US) | 1990-12-11 | — | — | US | disclosed |
| US-4738986-A | CYCLOOXYGENASE, LIDOXYGENASE INHIBITORS | BURROUGHS WELLCOME CO. (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0196184-A2 | Aryl derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-10-01 | — | — | EP | disclosed |