Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 6/20 | 0.66 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.66 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.66 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.66 |
| ▸ | MAOA | P21397 | 1/20 | 0.66 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.66 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.66 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.66 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.66 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL903704 | 0.85 | SIGMAR1 (0.63) | TAAR1SIGMAR1SLC18A2ALDH1A1CYP3A4 | |
| SCHEMBL29020992 | 0.82 | SIGMAR1 (0.55) | TAAR1SIGMAR1SLC18A2ALDH1A1CYP3A4 | |
| Levamfetamine SCHEMBL9673275 | 0.81 | SLC6A2 (1.00) | TAAR1SIGMAR1SLC6A4SLC6A2MAOA | |
| Amphetamine SCHEMBL13746679 | 0.81 | SLC6A2 (1.00) | TAAR1SIGMAR1SLC6A4SLC6A2MAOA | |
| Amphetamine SCHEMBL8858 | 0.81 | SLC6A2 (1.00) | TAAR1SIGMAR1SLC6A4SLC6A2MAOA | |
| Amphetamine SCHEMBL13747801 | 0.81 | SLC6A2 (1.00) | TAAR1SIGMAR1SLC6A4SLC6A2MAOA | |
| Amphetamine SCHEMBL15094242 | 0.81 | SLC6A2 (1.00) | TAAR1SIGMAR1SLC6A4SLC6A2MAOA | |
| Dextroamphetamine SCHEMBL8859 | 0.81 | SLC6A2 (1.00) | TAAR1SIGMAR1SLC6A4SLC6A2MAOA | |
| Amphetamine SCHEMBL1560962 | 0.81 | SLC6A2 (1.00) | TAAR1SIGMAR1SLC6A4SLC6A2MAOA | |
| Amphetamine SCHEMBL910141 | 0.81 | SLC6A2 (1.00) | TAAR1SIGMAR1SLC6A4SLC6A2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130195935-A1 | ABUSE-PROOFED DOSAGE FORM | GRUNENTHAL GMBH (DE) | 2013-08-01 | — | — | US | claimed |
| US-20120308654-A1 | ABUSE-PROOFED DOSAGE FORM | GRUNENTHAL GMBH (DE) | 2012-12-06 | — | — | US | claimed |
| US-7776314-B2 | Abuse-proofed dosage system | GRUNENTHAL GMBH (DE) | 2010-08-17 | — | — | US | claimed |
| US-20050152843-A1 | Abuse-proofed dosage form | GRUNENTHAL GMBH (DE) | 2005-07-14 | — | — | US | claimed |
| US-20150182464-A1 | PROCESS FOR THE PRODUCTION OF AN ABUSE-PROOFED SOLID DOSAGE FORM | GRUENENTHAL GMBH (DE) | 2015-07-02 | — | — | US | disclosed |
| US-20110009669-A1 | ABUSE-RESISTANT AMPHETAMINE PRODRUGS | SHIRE LLC (US) | 2011-01-13 | — | — | US | disclosed |
| US-20100292337-A1 | Polar Hydrophilic Prodrugs of Amphetamine and Other Stimulants and Processes for Making and Using the Same | SHIRE LLC | 2010-11-18 | — | — | US | disclosed |
| US-20070065365-A1 | Abuse-resistant transdermal system | GRUENENTHAL GMBH (DE) | 2007-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292337-A1 | Polar Hydrophilic Prodrugs of Amphetamine and Other Stimulants and Processes for Making and Using the Same | SLC6A2, SLC6A3, SLC18A2 | TAAR1 34/4885SIGMAR1 35/4885SLC6A4 13/4885 |
| US-20110009669-A1 | ABUSE-RESISTANT AMPHETAMINE PRODRUGS | COMT, CYP3A5, CYP2D6 | TAAR1 161/4885SIGMAR1 134/4885SLC6A4 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.