Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 1/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.42 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 6/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9708190 | 0.94 | AGTR1 (0.43) | PDE1APDE1BPDE1CAGTR1AGTR2 | |
| SCHEMBL9708497 | 0.93 | RAB9A (0.43) | AGTR1AGTR2NPSR1TSHRLMNA | |
| SCHEMBL9708698 | 0.93 | ADORA3 (0.43) | AGTR1AGTR2 | |
| SCHEMBL9707555 | 0.92 | AGTR1 (0.48) | AGTR1AGTR2 | |
| SCHEMBL9708105 | 0.92 | ADORA3 (0.42) | AGTR1AGTR2 | |
| SCHEMBL9707700 | 0.92 | AGTR1 (0.42) | AGTR1AGTR2 | |
| SCHEMBL9707579 | 0.92 | AGTR1 (0.44) | AGTR1AGTR2NPSR1TSHRHSD17B10 | |
| SCHEMBL9707554 | 0.91 | AGTR1 (0.45) | AGTR1AGTR2PDE5A | |
| SCHEMBL9709079 | 0.91 | PDE1A (0.43) | PDE1APDE1BPDE1CNPSR1TSHR | |
| SCHEMBL9708492 | 0.91 | AGTR1 (0.41) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992007852-A1 | BIPHENYLALKYL XANTHINE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1992-05-14 | — | — | WO | disclosed |