Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9708587 | 0.90 | AGTR1 (0.45) | KDM4EALDH1A1HTTMAPTHPGD | |
| SCHEMBL9708009 | 0.89 | CXCL8 (0.39) | KDM4EALDH1A1HTTMAPTHPGD | |
| SCHEMBL9708366 | 0.88 | BRAF (0.48) | KDM4EALDH1A1HTTMAPTHPGD | |
| SCHEMBL9707926 | 0.88 | AGTR2 (0.46) | MEN1KMT2AAGTR1AGTR2 | |
| SCHEMBL9707767 | 0.88 | MEN1 (0.50) | KDM4EALDH1A1HTTMAPTHPGD | |
| SCHEMBL9708221 | 0.88 | MEN1 (0.41) | KDM4EALDH1A1HTTMAPTHPGD | |
| SCHEMBL9707732 | 0.87 | ALDH1A1 (0.47) | KDM4EALDH1A1HTTMAPTHPGD | |
| SCHEMBL9707742 | 0.87 | AGTR2 (0.49) | AGTR1AGTR2 | |
| SCHEMBL9707935 | 0.87 | AGTR1 (0.39) | ALDH1A1AGTR1AGTR2 | |
| SCHEMBL9708479 | 0.86 | AGTR2 (0.46) | MEN1KMT2AAGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992007852-A1 | BIPHENYLALKYL XANTHINE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1992-05-14 | — | — | WO | disclosed |