Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11436628 | 0.83 | HTT (0.50) | HTTMAPK1NPSR1ALDH1A1KDM4E | |
| SCHEMBL10719836 | 0.70 | MAPK1 (0.40) | HTTMAPK1NPSR1ALDH1A1KDM4E | |
| SCHEMBL4397011 | 0.69 | HTT (0.92) | HTTMAPK1NPSR1ALDH1A1KDM4E | |
| SCHEMBL2454323 | 0.68 | HPGD (0.57) | MAPK1NPSR1ALDH1A1HPGDEPHX1 | |
| SCHEMBL7519998 | 0.68 | SMN1; SMN2 (0.40) | MAPK1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL4756400 | 0.68 | APLNR (0.36) | SMN1; SMN2 | |
| SCHEMBL28456420 | 0.68 | GAA (0.33) | SMN1; SMN2 | |
| SCHEMBL10366988 | 0.67 | ALDH1A1 (0.48) | ALDH1A1HPGDSMN1; SMN2EPHX2LMNA | |
| SCHEMBL4811500 | 0.67 | HTT (0.61) | HTTMAPK1ALDH1A1KDM4EEPHX1 | |
| SCHEMBL4811491 | 0.67 | HTT (0.61) | HTTMAPK1ALDH1A1KDM4EEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0220034-B1 | MALONATE DERIVATIVES USEFUL AS LIGHT STABILIZERS FOR PLASTICS | ICI AMERICAS INC. (US) | 1992-06-24 | — | — | EP | disclosed |
| US-4710527-A | STERICALLY HINDERED SPIROACETALS OF POLYALKYLPIPERIDIN-4-ONES | ICI AMERICAS INC. (US) | 1987-12-01 | — | — | US | disclosed |
| US-4701485-A | Malonate-based light stabilizers for plastics | ICI AMERICAS INC. (US) | 1987-10-20 | — | — | US | disclosed |
| EP-0222512-A2 | Malonate compounds useful as light stabilizers for plastics | CYTEC TECHNOLOGY CORP. (US) | 1987-05-20 | — | — | EP | disclosed |
| EP-0220034-A2 | Malonate derivatives useful as light stabilizers for plastics | ICI AMERICAS INC. (US) | 1987-04-29 | — | — | EP | disclosed |