Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9708653 | 0.83 | HTT (0.47) | HTTMAPK1NPSR1EPHX1NPC1 | |
| SCHEMBL4811500 | 0.72 | HTT (0.61) | HTTMAPK1EPHX1RAB9ASMN1; SMN2 | |
| SCHEMBL4811491 | 0.72 | HTT (0.61) | HTTMAPK1EPHX1RAB9ASMN1; SMN2 | |
| SCHEMBL9869403 | 0.72 | HSD11B1 (0.47) | SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4397011 | 0.71 | HTT (0.92) | HTTMAPK1NPSR1SMN1; SMN2KDM4E | |
| SCHEMBL10986126 | 0.70 | SIGMAR1 (0.48) | MAPK1NPSR1EPHX1NPC1RAB9A | |
| SCHEMBL27979494 | 0.69 | HTT (0.88) | HTTMAPK1NPSR1SMN1; SMN2KDM4E | |
| SCHEMBL4559772 | 0.69 | HTT (0.88) | HTTMAPK1NPSR1SMN1; SMN2KDM4E | |
| SCHEMBL5195912 | 0.68 | HTT (0.55) | HTTMAPK1EPHX1NPC1RAB9A | |
| SCHEMBL11658344 | 0.68 | SIGMAR1 (0.46) | MAPK1NPSR1EPHX1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4240954-A | CYCLOHEXYL UREAS OR THIOUREAS | AMERICAN CYANAMID COMPANY (US) | 1980-12-23 | — | — | US | disclosed |