Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD38 | P28907 | 6/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | PRKX | P51817 | 1/20 | 0.41 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.41 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.41 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9709748 | 0.86 | KMT2A (0.56) | CD38CYP3A4KCNH2POLBMEN1 | |
| SCHEMBL9709713 | 0.79 | LMNA (0.52) | LMNAMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL3924829 | 0.79 | HTT (0.75) | LMNAMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL31690902 | 0.76 | LMNA (0.42) | LMNAPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL3424865 | 0.75 | POLB (0.76) | CYP3A4LMNAPOLBMEN1KMT2A | |
| SCHEMBL440957 | 0.74 | LMNA (0.59) | CYP3A4LMNAPOLBMEN1KMT2A | |
| SCHEMBL20320534 | 0.73 | LMNA (0.45) | LMNAPOLBALDH1A1TSHRRXFP1 | |
| SCHEMBL30681299 | 0.73 | POLB (0.58) | CYP3A4LMNAPOLBMEN1KMT2A | |
| SCHEMBL5802951 | 0.73 | LMNA (0.58) | CYP3A4LMNAPOLBMEN1KMT2A | |
| SCHEMBL18216600 | 0.72 | SLC40A1 (0.51) | LMNAPOLBMEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992022533-A1 | 4-AMINOQUINOLINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | THE UPJOHN COMPANY (US) | 1992-12-23 | — | — | WO | disclosed |