Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | ESRRG | P62508 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.35 |
| ▸ | RELA | Q04206 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11516166 | 0.75 | ALDH1A1 (0.51) | ALDH1A1MAPTNPSR1LMNAHSP90AA1 | |
| SCHEMBL23368374 | 0.66 | ALDH1A1 (0.52) | ALDH1A1MAPTNPSR1LMNAHSP90AA1 | |
| SCHEMBL13403334 | 0.66 | TSHR (0.44) | ALDH1A1MAPTNPSR1LMNAHSP90AA1 | |
| SCHEMBL5026702 | 0.65 | MAPT (0.59) | ALDH1A1MAPTNPSR1LMNASMN1; SMN2 | |
| SCHEMBL9711221 | 0.65 | ALDH1A1 (0.50) | ALDH1A1MAPTLMNASMN1; SMN2NPC1 | |
| SCHEMBL11872600 | 0.65 | HPGD (0.42) | ALDH1A1MAPTNPSR1LMNAHSP90AA1 | |
| SCHEMBL19154876 | 0.64 | TSHR (0.42) | ALDH1A1MAPTNPSR1LMNAHSP90AA1 | |
| Hydrogen Peroxide SCHEMBL28677809 | 0.64 | LMNA (0.71) | ALDH1A1MAPTLMNASMN1; SMN2SRD5A2 | |
| SCHEMBL5608985 | 0.64 | GRIA4 (0.41) | ALDH1A1LMNASMN1; SMN2KIF11TP53 | |
| SCHEMBL11863781 | 0.64 | CTSD (0.43) | ALDH1A1MAPTNPSR1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153227-A | Treatment of diabetes and galactosemia complications | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-10-06 | — | — | US | disclosed |
| EP-0304190-B1 | (ARYLSULPHONYL)NITROMETHANES, PROCESS FOR THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-07-08 | — | — | EP | disclosed |
| EP-0304190-A1 | (Arylsulphonyl)nitromethanes, process for their preparation and use in pharmaceutical compositions | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-02-22 | — | — | EP | disclosed |